- ►fafp.org [PDF] RA DeFronzo - Medical Clinics of North America, 2004 - Elsevier A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of mechanisms
involved in the maintenance of normal glucose homeostasis in the basal or postabsorptive state
(10–12 h overnight fast) and following ingestion of a typical mixed meal [1, 2, 3, 4, 5, 6, 7, ... Cited by 694 - Related articles - BL Direct - All 5 versions
JE Gerich, C Meyer, HJ Woerle, M Stumvoll - Diabetes Care, 2001 - Am Diabetes Assoc Studies conducted over the last 60 years in animals and in vitro have provided considerable
evidence that the mammalian kidney can make glucose and release it under various
conditions. Until quite recently, however, it was generally believed that the human kidney ... Cited by 100 - Related articles - All 5 versions
- ►nih.gov SJ Fisher, CR Kahn - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig We and others have suggested that insulin predominantly acts indirectly to inhibit hepatic glucose
production (HGP) via suppression of gluconeogenic precursors, FFAs, and glucagon. To test
that hypothesis, we performed high-dose hyperinsulinemic-euglycemic clamps using [3- 3 ... Cited by 92 - Related articles - BL Direct - All 7 versions
K Dhatariya, ML Bigelow, KS Nair - Diabetes, 2005 - Am Diabetes Assoc DHEA (dehydroepiandrosterone) replacement is not part of the current standard of care in hypoadrenal
subjects. Animal studies have shown that DHEA administration prevents diabetes. To determine
the physiological effect of DHEA replacement on insulin sensitivity in adrenal-deficient ... Cited by 50 - Related articles - All 5 versions
M Roden, E Bernroider - Best Practice & Research Clinical Endocrinology & …, 2003 - Elsevier The liver is mainly responsible for maintaining normal concentrations of blood glucose by its
ability to store glucose as glycogen and to produce glucose from glycogen breakdown or gluconeogenic
precursors. During the last decade, new techniques have made it possible to gain further ... Cited by 48 - Related articles - All 3 versions
- ►endojournals.org A Thorell, O Rooyackers, P Myrenfors, M Soop, … - Journal of Clinical …, 2004 - Endocrine Soc At basal and TPN, concentrations of glucose and insulin were higher in patients (P < 0.05). During
TPN+I, insulin concentrations were 30-fold higher in patients. At basal, WGD and EGP were
30% higher in patients (P < 0.05). During TPN, EGP decreased in both groups but less in ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►physiology.org C Meyer, JM Dostou, SL Welle, JE … - American Journal of …, 2002 - Am Physiological Soc Recent studies indicate a role for the kidney in postabsorptive glucose homeostasis. The present
studies were undertaken to evaluate the role of the kidney in postprandial glucose homeostasis
and to compare its contribution to that of liver and skeletal muscle. Accordingly, we used ... Cited by 39 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] E Cersosimo, P Garlick, J Ferretti - Diabetes, 2000 - Am Diabetes Assoc To examine the potential contribution of precursor sub- strates to renal gluconeogenesis during
hypoglycemia, 14 healthy subjects had arterialized hand vein and renal vein (under
fluoroscopy) catheterized after an overnight fast. Net renal balance of lactate, glycerol, ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►physiology.org A Battezzati, A Caumo, F Martino, LP … - American Journal of …, 2004 - Am Physiological Soc Extrahepatic glucose release was evaluated during the anhepatic phase of liver transplantation
in 14 recipients for localized hepatocarcinoma with mild or absent cirrhosis, who received a bolus
of [6,6- 2 H 2 ]glucose and L-[3- 13 C]alanine or L-[1,2- 13 C 2 ]glutamine to measure ... Cited by 33 - Related articles - BL Direct - All 5 versions
J Radziuk, S Pye - Diabetologia, 2002 - Springer The rate of endogenous glucose production (EGP) is important in understanding the pathophysiology
of Type II (non-insulin-dependent) diabetes mellitus, the aetiology of its complications, and the
identification of potential therapeutic targets. A great deal of effort has therefore been ... Cited by 34 - Related articles - BL Direct - All 4 versions
