- ►diabetesjournals.org DJ Drucker - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide
(GIP) exert important effects on β-cells to stimulate glucose-dependent insulin secretion. Both
peptides also regulate β-cell proliferation and cytoprotection. GLP-1, but not GIP, inhibits ... Cited by 284 - Related articles - All 13 versions
CB Juhl, M Hollingdal, J Sturis, G Jakobsen, H Agersø, … - Diabetes, 2002 - Am Diabetes Assoc Glucagon-like peptide 1 (GLP-1) is a potent glucose-lowering agent of potential interest for the
treatment of type 2 diabetes. To evaluate actions of NN2211, a long-acting GLP-1 derivative,
we examined 11 patients with type 2 diabetes, age 59 ± 7 years (mean ± SD), BMI 28.9 ± ... Cited by 175 - Related articles - BL Direct - All 6 versions
- ►endojournals.org F Fehse, M Trautmann, JJ Holst, AE Halseth, N … - Journal of Clinical …, 2005 - Endocrine Soc Context: First-phase insulin secretion (within 10 min after a sudden rise in plasma glucose) is
reduced in type 2 diabetes mellitus (DM2). The incretin mimetic exenatide has glucoregulatory
activities in DM2, including glucose-dependent enhancement of insulin secretion. Cited by 123 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2 diabetics. It was found
that islet function was about 50% of normal at the time of diagnosis, and a reduction in ß-cell
mass of about 60% was shown at necropsy. The reduction of ß-cell mass is attributable to ... Cited by 105 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org LL Kjems, BM Kirby, EM Welsh, JD Veldhuis, M … - Diabetes, 2001 - Am Diabetes Assoc Most insulin is secreted in discrete pulses at an interval of ∼6 min. Increased insulin secretion
after meal ingestion is achieved through the mechanism of amplification of the burst mass.
Conversely, in type 2 diabetes, insulin secretion is impaired as a consequence of ... Cited by 74 - Related articles - BL Direct - All 6 versions
JJ Meier, MA Nauck - Diabetes/Metabolism Reviews - interscience.wiley.com Post-translational proteolytic processing of the preproglucagon gene in the gut results in the
formation of glucagon-like peptide 1 (GLP-1). Owing to its glucose-dependent insulinotropic
effect, this hormone was postulated to primarily act as an incretin, ie to augment insulin ... Cited by 73 - Related articles - All 3 versions
O Dyachok, Y Isakov, J Sagetorp, A Tengholm - Nature, 2006 - unil.ch Cyclic AMP is a ubiquitous second messenger that transduces signals from a variety of cell surface
receptors to regulate diverse cellular functions, including secretion, metabolism and gene
transcription. In pancreatic b-cells, cAMP potentiates Ca2+- dependent exocytosis1–3 ... Cited by 67 - Related articles - View as HTML - BL Direct - All 9 versions
- ►diabetesjournals.org MA Nauck, B Baller, JJ Meier - Diabetes, 2004 - Am Diabetes Assoc The incretin effect denominates the phenomenon that oral glucose elicits a higher insulin response
than does intravenous glucose. The two hormones responsible for the incretin effect,
glucose-dependent insulinotropic hormone (GIP) and glucagon-like peptide-1 (GLP-1), ... Cited by 61 - Related articles - BL Direct - All 5 versions
- ►nih.gov KW Sloop, JXC Cao, AM Siesky, HY Zhang … - Journal of Clinical …, 2004 - Am Soc Clin Investig Uncontrolled hepatic glucose production contributes significantly to hyperglycemia in patients
with type 2 diabetes. Hyperglucagonemia is implicated in the etiology of this condition;
however, effective therapies to block glucagon signaling and thereby regulate glucose ... Cited by 47 - Related articles - BL Direct - All 6 versions
