- ►aspetjournals.org ME Doyle, JM Egan - Pharmacological reviews, 2003 - ASPET Blood glucose levels are sensed and controlled by the release of hormones from
the islets of Langerhans in the pancreas. The -cell, the insulin-secreting cell
in the islet, can detect subtle increases in circulating glucose levels and ... Cited by 82 - Related articles - BL Direct - All 8 versions
- ►bcell.org [PDF] PE MacDonald, MB Wheeler - Diabetologia, 2003 - Springer Insulin secretion from pancreatic islet beta cells is acutely regulated by a
complex interplay of metabolic and electrogenic events. The electrogenic
mechanism regulating insulin secretion from beta cells is com- monly ... Cited by 74 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JC Henquin - Diabetes, 2004 - Am Diabetes Assoc Physiologically, insulin secretion is subject to a dual, hierarchal control by
triggering and amplifying pathways. By closing ATP-sensitive K + channels (K ATP
channels) in the plasma membrane, glucose and other metabolized nutrients ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S Efendic, AM Efanov, PO Berggren, SV … - Diabetes, 2002 - Am Diabetes Assoc The imidazoline RX871024 increased basal- and glucose-stimulated insulin release
in vitro and in vivo. The compound inhibited activity of ATP-sensitive K +
channels as well as voltage-gated K + channels, which led to membrane ... Cited by 26 - Related articles - BL Direct - All 4 versions
I Rustenbeck - Biochemical pharmacology, 2002 - Elsevier Desensitization of insulin secretion describes a reversible state of decreased
secretory responsiveness of the pancreatic β-cell, induced by a prolonged
exposure to a multitude of stimuli. These include the main physiological ... Cited by 24 - Related articles - BL Direct - All 5 versions
M Høy, HL Olsen, HS Andersen, K Bokvist, K … - European journal of pharmacology, 2003 - Elsevier We have investigated the effects of the novel imidazoline compound (+)-2-(2-(4,5
-dihydro-1H-imidazol-2-yl)-thiopene-2-yl-ethyl)-pyridine (NNC77-0074) on
stimulus-secretion coupling in isolated pancreatic α- and β-cells. ... Cited by 17 - Related articles - All 5 versions
GA Head, DN Mayorov - Cardiovascular &# 38; Hematological Agents in …, 2006 - ingentaconnect.com Abstract: The initial realization that agents containing an imidazoline
structure may interact with a distinct class of receptors, has led to a major
class of cardiovascular agents, which now has the potential to enter a ... Cited by 16 - Related articles - BL Direct - All 2 versions
- ►cell.com A Nourparvar, A Bulotta, U Di Mario, R Perfetti - Trends in Pharmacological Sciences, 2004 - Elsevier Type 2 diabetes is characterized by high concentrations of glucose in the blood,
which is caused by decreased secretion of insulin from the pancreas and
decreased insulin action. This condition is prevalent worldwide and is ... Cited by 17 - Related articles - All 5 versions
- ►diabetesjournals.org I Rustenbeck, A Wienbergen, C Bleck, A Jörns - Diabetes, 2004 - Am Diabetes Assoc Prolonged stimulation of insulin secretion by depolarization and Ca 2+ influx
regularly leads to a reversible state of decreased secretory responsiveness to
nutrient and nonnutrient stimuli. This state is termed "desensitization." ... Cited by 13 - Related articles - BL Direct - All 4 versions
MB Brenner, J Gromada, AM Efanov, K Bokvist … - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2003 - interscience.wiley.com Abstract: The effect of the imidazoline compound LY374284 has been studied in
pancreatic islets of db/db mice, a progressive model of diabetes. In perifusion
experiments, pancreatic islets of db/db mice showed a progressive ... Cited by 12 - Related articles - BL Direct - All 4 versions
