- ►endojournals.org JL Evans, ID Goldfine, BA Maddux, GM … - Endocrine Reviews, 2002 - Endocrine Soc In both type 1 and type 2 diabetes, the late diabetic complications in nerve,
vascular endothelium, and kidney arise from chronic elevations of glucose and
possibly other metabolites including free fatty acids (FFA). Recent ... Cited by 593 - Related articles - BL Direct - All 18 versions
- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for
causing insulin resistance and pancreatic ß-cell failure and the precise
sequence of events leading to the development of type 2 diabetes are not ... Cited by 514 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org A Ceriello, E Motz - Arteriosclerosis, thrombosis, and vascular biology, 2004 - Am Heart Assoc Type 2 diabetes is a worldwide increasing disease resulting from the interaction
between a subject's genetic makeup and lifestyle. In genetically predisposed
subjects, the combination of excess caloric intake and reduced physical ... Cited by 383 - Related articles - BL Direct - All 9 versions
JL Evans, ID Goldfine, BA Maddux, GM … - Diabetes, 2003 - Am Diabetes Assoc In both type 1 and type 2 diabetes, diabetic complications in target organs
arise from chronic elevations of glucose. The pathogenic effect of high glucose,
possibly in concert with fatty acids, is mediated to a significant extent ... Cited by 365 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org CB Chan, D De Leo, JW Joseph, TS McQuaid, … - Diabetes, 2001 - Am Diabetes Assoc In pancreatic β-cells, glucose metabolism signals insulin secretion by altering
the cellular array of messenger molecules. ATP is particularly important, given
its role in regulating cation channel activity, exocytosis, and events ... Cited by 206 - Related articles - BL Direct - All 5 versions
P Rorsman, E Renström - Diabetologia, 2003 - Springer Glucose-induced insulin secretion in response to a step increase in blood
glucose concentrations follows a bi- phasic time course consisting of a rapid
and transient first phase followed by a slowly developing and sus- tained ... Cited by 205 - Related articles - BL Direct - All 3 versions
- ►nih.gov S Krauss, CY Zhang, L Scorrano, LT Dalgaard, … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Failure to secrete adequate amounts of insulin in response to increasing
concentrations of glucose is an important feature of type 2 diabetes. The
mechanism for loss of glucose responsiveness is unknown. Uncoupling protein ... Cited by 192 - Related articles - BL Direct - All 11 versions
- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of β cell compensation for insulin resistance, ... Cited by 196 - Related articles - BL Direct - All 7 versions
MD Brand, TC Esteves - Cell Metabolism, 2005 - Elsevier Uncoupling proteins (UCPs) have become prominent in the fields of thermogenesis,
obesity, diabetes, and free radical biology following the discovery of a family
of novel UCPs and have recently started to make an impact in the areas of ... Cited by 179 - Related articles - All 10 versions
- ►endojournals.org I Kharroubi, L Ladriere, AK Cardozo, Z … - Endocrinology, 2004 - Endocrine Soc Apoptosis is probably the main form of ß-cell death in both type 1 diabetes
mellitus (T1DM) and T2DM. In T1DM, cytokines contribute to ß-cell destruction
through nuclear factor- B (NF- B) activation. Previous studies suggested ... Cited by 134 - Related articles - BL Direct - All 3 versions
