- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for causing insulin resistance
and pancreatic ß-cell failure and the precise sequence of events leading to the development
of type 2 diabetes are not yet fully understood. Abnormalities of triglyceride storage and ... Cited by 525 - Related articles - BL Direct - All 6 versions
G Boden, GI Shulman - European Journal of Clinical …, 2002 - interscience.wiley.com Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart, liver
and pancreas. However, chronically elevated plasma FFA appear to have pathophysiological
consequences. Elevated FFA concentrations are linked with the onset of peripheral and ... Cited by 491 - Related articles - BL Direct - All 3 versions
- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & …, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle and
impaired insulin secretion. Considerable evidence also implicates deranged adipocyte metabolism
and altered fat topography in the pathogenesis of glucose intolerance in T2DM. 1) Fat ... Cited by 245 - Related articles - All 4 versions
KF Petersen, S Dufour, D Befroy, M Lehrke, RE … - Diabetes, 2005 - Am Diabetes Assoc To examine the mechanism by which moderate weight reduction improves basal and
insulin-stimulated rates of glucose metabolism in patients with type 2 diabetes, we used 1 H
magnetic resonance spectroscopy to assess intrahepatic lipid (IHL) and intramyocellular ... Cited by 221 - Related articles - All 6 versions
N Shojima, H Sakoda, T Ogihara, M Fujishiro, H … - Diabetes, 2002 - Am Diabetes Assoc Resistin is a hormone secreted by adipocytes that acts on skeletal muscle myocytes,
hepatocytes, and adipocytes themselves, reducing their sensitivity to insulin. In the present
study, we investigated how the expression of resistin is affected by glucose and by ... Cited by 153 - Related articles - BL Direct - All 3 versions
- ►physiology.org TKT Lam, A Carpentier, GF Lewis, G van … - American Journal of …, 2003 - Am Physiological Soc The associations between obesity, insulin resistance, and type 2 diabetes mellitus are well
documented. Free fatty acids (FFA), which are often elevated in obesity, have been implicated
as an important link in these associations. Contrary to muscle glucose metabolism, the ... Cited by 149 - Related articles - BL Direct - All 4 versions
M Gil-Campos, R Cañete, A Gil - Clinical Nutrition, 2004 - Elsevier Obesity and insulin resistance have been recognised as leading causes of major health
issues, particularly diabetes type 2 and metabolic syndrome. Although obesity, defined as excess
body fat, is frequently accompanied by insulin resistance, diabetes, metabolic syndrome ... Cited by 134 - Related articles - All 10 versions
- ►physiology.org G Boden, P Cheung, TP Stein, K Kresge, … - American Journal of …, 2002 - Am Physiological Soc Free fatty acids (FFA) have been shown to inhibit insulin suppression of endogenous glucose
production (EGP). To determine whether this is the result of stimulation by FFA of gluconeogenesis
(GNG) or glycogenolysis (GL) or a combination of both, we have determined rates of GNG ... Cited by 121 - Related articles - BL Direct - All 5 versions
- ►yu.edu [PDF] TKT Lam, A Pocai, R Gutierrez-Juarez, S Obici, J … - Nature medicine, 2005 - medscape.com Increased glucose production is a hallmark of type 2 diabetes and alterations in lipid metabolism
have a causative role in its pathophysiology. Here we postulate that physiological increments
in plasma fatty acids can be sensed within the hypothalamus and that this sensing is ... Cited by 118 - Related articles - All 9 versions
- ►physiology.org DB Savage, KF Petersen, GI Shulman - Physiological reviews, 2007 - Am Physiological Soc Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts
for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM
are increasingly focused on disordered lipid metabolism. Here we review recent human ... Cited by 113 - Related articles - BL Direct - All 5 versions
