- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, R … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and
pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable
abnormality is insulin resistance in skeletal muscle. Impaired ... Cited by 663 - Related articles - BL Direct - All 15 versions
DE Kelley, J He, EV Menshikova, VB Ritov - Diabetes, 2002 - Am Diabetes Assoc Skeletal muscle is strongly dependent on oxidative phosphorylation for energy
production. Because the insulin resistance of skeletal muscle in type 2 diabetes
and obesity entails dysregulation of the oxidation of both carbohydrate and ... Cited by 531 - Related articles - BL Direct - All 4 versions
- ►nih.gov GD Barish, VA Narkar, RM Evans - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Obesity is a growing threat to global health by virtue of its association with
insulin resistance, glucose intolerance, hypertension, and dyslipidemia,
collectively known as the metabolic syndrome or syndrome X. The nuclear ... Cited by 239 - Related articles - BL Direct - All 7 versions
- Free from Publisher DE Kelley, BH Goodpaster - Diabetes Care, 2001 - Am Diabetes Assoc Recent evidence derived from four independent methods indicates that an excess
triglyceride storage within skeletal muscle is linked to insulin resistance.
Potential mechanisms for this association include apparent defects in fatty ... Cited by 223 - Related articles - BL Direct - All 8 versions
- ►nih.gov CS Stump, KR Short, ML Bigelow, JM Schimke … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Mitochondria are the primary site of skeletal muscle fuel metabolism and ATP
production. Although insulin is a major regulator of fuel metabolism, its effect
on mitochondrial ATP production is not known. Here we report increases in ... Cited by 133 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org JM Adams, T Pratipanawatr, R Berria, E … - Diabetes, 2004 - Am Diabetes Assoc Increased intramyocellular lipid concentrations are thought to play a role in
insulin resistance, but the precise nature of the lipid species that produce
insulin resistance in human muscle are unknown. Ceramides, either generated ... Cited by 117 - Related articles - BL Direct - All 9 versions
- ►asnjournals.org SP Bagby - Journal of the American Society of Nephrology, 2004 - Am Soc Nephrol Metabolic syndrome, originally described in 1988 as "syndrome X" by Reaven et
al. (1), has evolved in our collective thinking from a vague association of
common chronic disease states to a formally defined cluster of clinical ... Cited by 109 - Related articles - BL Direct - All 4 versions
K Højlund, K Wrzesinski, PM Larsen, SJ Fey, … - Journal of Biological Chemistry, 2003 - ASBMB Insulin resistance in skeletal muscle is a hallmark feature of type 2 diabetes.
An increasing number of enzymes and metabolic pathways have been implicated in
the development of insulin resistance. However, the primary cellular cause ... Cited by 92 - Related articles - BL Direct - All 5 versions
- ►physiology.org MJ Watt, GJF Heigenhauser, LL Spriet - Journal of Applied Physiology, 2002 - Am Physiological Soc Intramuscular triacylglyerols (IMTGs) represent a potentially important energy
source for contracting human skeletal muscle. Although the majority of evidence
from isotope tracer and 1 H-magnetic resonance spectroscopy (MRS) studies ... Cited by 87 - Related articles - BL Direct - All 4 versions
CR Bruce, AL Carey, JA Hawley, MA Febbraio - Diabetes, 2003 - Am Diabetes Assoc To examine whether genes associated with cellular defense against oxidative
stress are associated with insulin sensitivity, patients with type 2 diabetes (n
= 7) and age-matched (n = 5) and young (n = 9) control subjects underwent a ... Cited by 87 - Related articles - BL Direct - All 4 versions
