D Meyre, N Bouatia-Naji, A Tounian, C Samson, … - Nature genetics, 2005 - pubmedcentral.nih.gov We identified a childhood obesity locus on chromosome 6q16.3-q24.2 1 that
includes 2.4 Mb common to eight genome scans for Type 2 diabetes (T2D) or
obesity 1 - 8 . Analysis of the ENPP1 (PC-1) gene, a candidate for insulin ... Cited by 161 - Related articles - BL Direct - All 10 versions
JW Goding, B Grobben, H Slegers - BBA-Molecular Basis of Disease, 2003 - Elsevier The ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP) multigene family
contains five members. NPP1-3 are type II transmembrane metalloenzymes
characterized by a similar modular structure composed of a short ... Cited by 100 - Related articles - All 4 versions
- ►endojournals.org N Abate, L Carulli, A Cabo-Chan Jr, M … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc Genetic susceptibility may be responsible for high prevalence of insulin
resistance in Asian Indians. This study was carried out in samples of local
Asian Indians and Caucasians to determine whether plasma cell membrane ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►kuleuven.be [PDF] C Stefan, S Jansen, M Bollen - Trends in biochemical sciences, 2005 - Elsevier Nucleotide pyrophosphatase/phosphodiesterase (NPP)-type ectophosphodiesterases
are found at the cell surface as type-I or type-II transmembrane proteins, but
are also found extracellularly as secreted or shedded enzymes. They ... Cited by 56 - Related articles - All 8 versions
S Bacci, O Ludovico, S Prudente, YY Zhang, R … - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery
disease (CAD). The K121Q polymorphism of the ENPP1/PC-1 gene is associated with
IR. Our aim was to investigate the role of the 121Q variant on the risk of ... Cited by 54 - Related articles - BL Direct - All 5 versions
L Frittitta, T Ercolino, M Bozzali, A Argiolas, … - Diabetes, 2001 - Am Diabetes Assoc Glycoprotein PC-1 inhibits insulin signaling and, when overexpressed, plays a
role in human insulin resistance. Mechanisms of PC-1 overexpression are unknown.
We have identified a haplotype in the 3′-untranslated region of the PC-1 ... Cited by 46 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Kubaszek, A Markkanen, JG Eriksson, T … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Birth weight and length serve as indicators of the intrauterine environment, and
a small body size at birth is a predictor of type 2 diabetes and hypertension.
Insulin is one of the growth factors regulating fetal growth. The plasma ... Cited by 45 - Related articles - BL Direct - All 5 versions
A Kubaszek, J Pihlajamäki, P Karhapää, I … - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—The 121Q allele (genotypes K121Q and Q121Q) compared with the K121K
genotype was related to higher fasting insulin levels (group I: 69.6 ± 45.6 vs.
51.9 ± 28.4 pmol/l [mean ± SD], P = 0.050; group II: 66.6 ± 38.8 vs. ... Cited by 44 - Related articles - BL Direct - All 5 versions
LH Canani, DPK Ng, A Smiles, JJ Rogus, JH … - Diabetes, 2002 - Am Diabetes Assoc A polymorphism in the ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene
(ENPP1) (previously known as PC-1), resulting in an amino acid change from
lysine to glutamine at codon 121 (K121Q), is associated with insulin ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►pubget.com [PDF] N Grarup, SA Urhammer, J Ek, A Albrechtsen, … - Diabetologia, 2006 - Springer Page 1. ARTICLE Studies of the relationship between the ENPP1 K121Q polymorphism
and type 2 diabetes, insulin resistance and obesity ... Cited by 41 - Related articles - BL Direct - All 5 versions
