- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is
without patients who have the disease. Whereas insulin insensitivity is an early
phenomenon partly related to obesity, pancreas β-cell function declines ... Cited by 433 - Related articles - All 17 versions
- ►oxfordjournals.org MS Sandhu, DB Dunger, EL Giovannucci - JNCI Journal of the National Cancer Institute, 2002 - jnci.oxfordjournals.org Secular changes and worldwide variations in incidence rates of colorectal
cancer, along with results from twin and migrant studies, provide compelling
evidence that environmental factors influence the risk of this disease. ... Cited by 168 - Related articles - BL Direct - All 7 versions
- ►fasebj.org G SESTI, M FEDERICI, ML HRIBAL, D … - The FASEB Journal, 2001 - FASEB Insulin receptor substrate (IRS) molecules are key mediators in insulin
signaling and play a central role in maintaining basic cellular functions such
as growth, survival, and metabolism. They act as docking proteins between ... Cited by 155 - Related articles - BL Direct - All 2 versions
P Marchetti, R Lupi, M Federici, L Marselli, M … - Diabetes, 2002 - Am Diabetes Assoc Type 2 (non–insulin-dependent) diabetes results from decreased insulin action
in peripheral target tissues (insulin resistance) and impaired pancreatic
β-cell function. These defects reflect both genetic components and ... Cited by 67 - Related articles - BL Direct - All 5 versions
ML Slattery, W Samowitz, K Curtin, KN Ma, … - Cancer Epidemiology Biomarkers & Prevention, 2004 - AACR Introduction: Insulin, insulin-like growth factor (IGF), and IGF binding protein
(IGFBP) are involved in cell growth and proliferation and are thought to be
important in the etiology of colorectal cancer. We hypothesize that genetic ... Cited by 56 - Related articles - BL Direct - All 4 versions
JC Florez, M Sjögren, N Burtt, M Orho- … - Diabetes, 2004 - Am Diabetes Assoc The insulin receptor substrate (IRS)-1 is an important component of the insulin
signal transduction cascade. Several reports suggest that a Gly→Arg change in
codon 972 is associated with type 2 diabetes and related traits, and a ... Cited by 49 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org RC Bonadonna, M Stumvoll, A Fritsche, M … - Diabetes, 2003 - Am Diabetes Assoc We adapted a minimal model to assess β-cell function during a hyperglycemic
glucose clamp and to uncover peculiar aspects of the relationship among β-cell
function, plasma glucose, and insulin sensitivity (IS) in offspring of ... Cited by 46 - Related articles - BL Direct - All 6 versions
- ►aacrjournals.org ML Slattery, W Samowitz, M Hoffman, KN Ma, … - Cancer Epidemiology Biomarkers & Prevention, 2004 - AACR Introduction: Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) have
been shown to reduce risk of colorectal cancer. Although inhibition of
cyclooxygenase (COX)-2 is generally thought to be the relevant mechanism, ... Cited by 46 - Related articles - BL Direct - All 4 versions
M Stumvoll, H Häring - Hormone Research, 2000 - content.karger.com Insulin resistance is a key factor in the pathogenesis of type 2 diabetes
mellitus and a co-factor in the development of dyslipidaemia, hypertension and
atherosclerosis. The causes of insulin resistance include factors such as ... Cited by 45 - Related articles - BL Direct - All 4 versions
M Stumvoll, N Stefan, A Fritsche, A Madaus, O … - Journal of Molecular Medicine, 2002 - Springer X/Arg (IRS-1) than in Pro/Pro (PPARγ 2 ) + X/Arg (IRS- 1). On the other hand,
insulin sensitivity was similar in the X/Ala (PPARγ 2 ) + Gly/Gly (IRS-1 972)
and the Pro/Pro (PPARγ 2 ) + Gly/Gly (IRS-1). The results were practically ... Cited by 34 - Related articles - BL Direct - All 3 versions
