JN Hirschhorn, K Lohmueller, E Byrne, K … - Genetics in …, 2002 - journals.lww.com Most common diseases are complex genetic traits, with multiple genetic and environmental components
contrib- uting to susceptibility. It has been proposed that common genetic variants, including
single nucleotide polymor- phisms (SNPs), influence susceptibility to common disease. ... Cited by 813 - Related articles - BL Direct - All 4 versions
J Ek, G Andersen, SA Urhammer, PH Gaede, T … - Diabetologia, 2001 - Springer Aim/hypothesis. This study aimed to investigate if variability in the peroxisome proliferator-activated
receptor-g coactivator-1 (PGC-1) gene is associated with Type II (non-insulin-dependent) diabetes
melli- tus. Methods. The PGC-1 gene was examined in 53 Type II diabetic patients ... Cited by 220 - Related articles - BL Direct - All 5 versions
M Stumvoll, H Häring - Diabetes, 2002 - Am Diabetes Assoc Peroxisome proliferator-activated receptor (PPAR)-γ is a transcription factor with a key role in
adipocyte differentiation. The Ala allele of the common Pro12Ala polymorphism in the isoform
PPAR-γ2 is associated with reduced risk for type 2 diabetes. The effect on the individual ... Cited by 187 - Related articles - BL Direct - All 5 versions
- ►physiology.org J Kaput, RL Rodriguez - Physiological genomics, 2004 - Am Physiological Soc The interface between the nutritional environment and cellular/genetic processes is being referred
to as "nutrigenomics." Nutrigenomics seeks to provide a molecular genetic understanding for
how common dietary chemicals (ie, nutrition) affect health by altering the expression ... Cited by 156 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org LJ Scott, LL Bonnycastle, CJ Willer, AG Sprau, AU … - Diabetes, 2006 - Am Diabetes Assoc Transcription factor 7-like 2 (TCF7L2) is part of the Wnt signaling pathway. Genetic variants within
TCF7L2 on chromosome 10q were recently reported to be associated with type 2 diabetes in
Icelandic, Danish, and American (US) samples. We previously observed a modest ... Cited by 139 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org VI Lindi, MIJ Uusitupa, J Lindström, A Louheranta, JG … - Diabetes, 2002 - Am Diabetes Assoc The association of the Pro12Ala polymorphism of the PPAR-γ2 gene with the incidence of type
2 diabetes was investigated in 522 subjects with impaired glucose tolerance (IGT) participating
in the Finnish Diabetes Prevention Study. Subjects were randomized to either an ... Cited by 108 - Related articles - BL Direct - All 7 versions
- ►oxfordjournals.org MI McCarthy - Human Molecular Genetics, 2004 - Oxford Univ Press The rapid increase in the prevalence of type 2 diabetes (T2D) represents a major challenge for
health care delivery worldwide. Identification of genes influencing individual susceptibility to
disease offers a route to better understanding of the molecular mechanisms underlying ... Cited by 94 - Related articles - All 4 versions
- ►bmj.com S Masud, S Ye - British Medical Journal, 2003 - jmg.bmj.com Peroxisome proliferator activated receptor- (PPAR- ) is a transcription factor abundantly expressed
in adipocytes, and plays a key role in the regulation of adipocyte differentiation, lipid storage,
glucose homeostasis, and blood pressure. 1 Several rare, dominant negative mutations ... Cited by 87 - Related articles - BL Direct - All 6 versions
- ►endojournals.org L Frederiksen, K Brodbaek, M Fenger, T … - Journal of Clinical …, 2002 - Endocrine Soc The Pro12Ala polymorphism of PPAR- 2 has been shown to influence insulin sensitivity and
the risk of type 2 diabetes in various ethnic populations. We examined whether the polymorphism
was related to the insulin resistance syndrome (IRS) among nondiabetic Danish subjects. ... Cited by 85 - Related articles - BL Direct - All 5 versions
J Robitaille, JP Despres, L Perusse, MC Vohl - Clinical genetics, 2003 - interscience.wiley.com The metabolic syndrome is a complex disorder characterized by an atherogenic dyslipidemia
resulting from the interaction between genetic and nutritional factors. The objective of this study
was to examine in a cohort of 720 adults participating in the Québec Family Study (QFS) ... Cited by 84 - Related articles - BL Direct - All 4 versions
