J Derbinski, A Schulte, B Kyewski, L Klein - nature immunology, 2001 - research4.dfci.harvard.edu Expression of peripheral antigens in the thymus has been implicated in T cell
tolerance and autoimmunity. Here we identified medullary thymic epithelial cells
as being a unique cell type that expresses a diverse range of ... Cited by 458 - Related articles - View as HTML - BL Direct - All 7 versions
- ►psu.edu [PDF] S Stamm, S Ben-Ari, I Rafalska, Y Tang, Z … - Gene, 2005 - Elsevier Alternative splicing is one of the most important mechanisms to generate a large
number of mRNA and protein isoforms from the surprisingly low number of human
genes. Unlike promoter activity, which primarily regulates the amount of ... Cited by 284 - Related articles - All 7 versions
- ►202.201.6.125 [PDF] B Kyewski, L Klein, 2006 - Annual Reviews Abstract Recent elucidation of the role of central tolerance in preventing
organ-specific autoimmunity has changed our concepts of self/nonself
discrimination. This paradigmatic shift is largely attributable to the ... Cited by 214 - Related articles - BL Direct - All 6 versions
- ►rupress.org J Gotter, B Brors, M Hergenhahn, B Kyewski - Journal of Experimental Medicine, 2004 - jem.rupress.org Promiscuous expression of tissue-specific self-antigens in the thymus imposes T
cell tolerance and protects from autoimmune diseases, as shown in animal
studies. Analysis of promiscuous gene expression in purified stromal cells ... Cited by 137 - Related articles - BL Direct - All 4 versions
- ►nih.gov A Pugliese, D Brown, D Garza, D Murchison, M … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Recent reports indicate that genes with tissue-restricted expression, including
those encoding the type 1 diabetes autoantigens insulin, glutamic acid
decarboxylase (GAD), and the tyrosine-phosphatase-like protein IA-2 (or ... Cited by 105 - Related articles - BL Direct - All 9 versions
T Ort, S Voronov, J Guo, K Zawalich, SC … - The EMBO journal, 2001 - pubmedcentral.nih.gov Islet cell autoantigen (ICA) 512 is a receptor-tyrosine phosphatase-like protein
associated with the secretory granules of neuroendocrine cells, including
pancreatic β-cells. Binding of its cytoplasmic tail to β2-syntrophin ... Cited by 75 - Related articles - BL Direct - All 3 versions
SM Lieberman, TP DiLorenzo - Tissue Antigens, 2003 - interscience.wiley.com Abstract: Type 1 diabetes (T1D) is an organ-specific autoimmune disease in which
the insulin-producing β cells in the pancreatic islets are selectively
eliminated. T cells specific for β-cell antigens are the mediators of this ... Cited by 60 - Related articles - BL Direct - All 5 versions
R Gianani, GS Eisenbarth - Immunological reviews, 2005 - interscience.wiley.com Summary: Type 1A diabetes is a chronic autoimmune disease usually preceded by a
long prodrome during which autoantibodies to islet autoantigens are present.
These antibodies are directed to a variety of antigens, but the best ... Cited by 42 - Related articles - All 4 versions
AG Thompson, R Thomas - Immunology and cell biology, 2002 - nature.com Dendritic cells (DC) have a key role in controlling the immune response, by
determining the outcome of antigen presentation to T cells. Through
costimulatory molecules and other factors, DC are involved in the ... Cited by 35 - Related articles - BL Direct - All 3 versions
- ►nih.gov B Han, P Serra, J Yamanouchi, A Amrani, JF … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig The progression of immune responses is generally associated with an increase in
the overall avidity of antigen-specific T cell populations for peptide-MHC. This
is thought to result from preferential expansion of high-avidity clonotypes ... Cited by 32 - Related articles - BL Direct - All 8 versions
