- ►fafp.org [PDF] RA DeFronzo - Medical Clinics of North America, 2004 - Elsevier A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of mechanisms
involved in the maintenance of normal glucose homeostasis in the basal or postabsorptive state
(10–12 h overnight fast) and following ingestion of a typical mixed meal [1, 2, 3, 4, 5, 6, 7, ... Cited by 694 - Related articles - BL Direct - All 5 versions
- ►pharmyaring.com [PDF] SE Inzucchi - Jama, 2002 - Am Med Assoc Context Care of patients with type 2 diabetes has been revolutionized throughout the past several
years—first, by the realization of the importance of tight glycemic control in forestalling
complications, and second, by the availability of several unique classes of oral ... Cited by 608 - Related articles - BL Direct - All 18 versions
R Lupi, F Dotta, L Marselli, S Del Guerra, M Masini, C … - Diabetes, 2002 - Am Diabetes Assoc In an effort to better understand the phenomenon of lipotoxicity in human β-cells, we evaluated
the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA) (2:1 oleate to
palmitate) on the function and survival of isolated human islets and investigated some of ... Cited by 270 - Related articles - BL Direct - All 7 versions
- ►ucsf.edu [PDF] GA Francis, E Fayard, F Picard, J Auwerx - Annual review of physiology, 2003 - Annual Reviews ▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological sensors, enabling
the organism to quickly adapt to environmental changes by inducing the appropriate metabolic
genes and pathways. Ligands for these metabolic receptors are compounds from dietary ... Cited by 258 - Related articles - BL Direct - All 7 versions
Y Li, T Hansotia, B Yusta, F Ris, PA Halban, DJ … - Journal of Biological …, 2003 - ASBMB Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion and augments β cell mass via activation
of β cell proliferation and islet neogenesis. We examined whether GLP-1 receptor signaling modifies
the cellular susceptibility to apoptosis. Mice administered streptozotocin (STZ), an agent ... Cited by 254 - Related articles - BL Direct - All 7 versions
- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & …, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle and
impaired insulin secretion. Considerable evidence also implicates deranged adipocyte metabolism
and altered fat topography in the pathogenesis of glucose intolerance in T2DM. 1) Fat ... Cited by 245 - Related articles - All 4 versions
RP Robertson - Journal of Biological Chemistry, 2004 - ASBMB Glucose in chronic excess causes toxic effects on structure and function of organs, including
the pancreatic islet. Multiple biochemical pathways and mechanisms of action for glucose toxicity
have been suggested. These include glucose autoxidation, protein kinase C activation, ... Cited by 223 - Related articles - BL Direct - All 6 versions
- ►endojournals.org L Farilla, H Hui, C Bertolotto, E Kang, A Bulotta, U Di … - Endocrinology, 2002 - Endocrine Soc A constant remodeling of islet cell mass mediated by proliferative and apoptotic stimuli ensures
a dynamic response to a changing demand for insulin. In this study, we investigated the effect
of glucagon-like peptide-1 (GLP-1) in Zucker diabetic rats, an animal model in which the ... Cited by 193 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org G Viberti, SE Kahn, DA Greene, WH Herman, B … - Diabetes Care, 2002 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—A Diabetes Outcome Progression Trial (ADOPT) is a
randomized, double-blind, parallel-group study consisting of a screening visit, a 4-week placebo
run-in, a 4-year treatment period, and an observational follow-up of ∼3,600 drug-naïve ... Cited by 168 - Related articles - BL Direct - All 14 versions
BJ Goldstein - The American journal of cardiology, 2002 - Elsevier Insulin resistance is a major contributor to the pathogenesis of type 2 diabetes and plays a key
role in associated metabolic abnormalities, such as dyslipidemia and hypertension. Obesity,
especially visceral adiposity, is negatively correlated with insulin sensitivity. The release ... Cited by 155 - Related articles - All 11 versions
