I Chang, S Kim, JY Kim, N Cho, YH Kim, HS Kim, MK … - Diabetes, 2003 - Am Diabetes Assoc Recent studies incriminating tumor necrosis factor (TNF)- as the final effector in pancreatic
ß-cell death in type 1 diabetes underscore the potential role of TNF- -dependent NF- B activation
as an important modulator of pancreatic ß-cell death in autoimmune diabetes. Although ... Cited by 46 - Related articles - BL Direct - All 5 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in beta-cell mass causing
insufficient insulin secretion. Beta-cell replacement strategies may eventually provide a cure
for diabetes. Current therapeutic approaches include pancreas and islet transplantation, ... Cited by 33 - Related articles - BL Direct - All 7 versions
- ►pnas.org S Kim, I Millet, HS Kim, JY Kim, MS Han, … - Proceedings of the …, 2007 - National Acad Sciences Whereas NF-κB has potent antiapoptotic function in most cell types, it was reported that in pancreatic
β cells it serves a proapoptotic function and may contribute to the pathogenesis of autoimmune
type 1 diabetes. To investigate the role of β cell NF-κB in autoimmune diabetes, we ... Cited by 31 - Related articles - BL Direct - All 10 versions
- ►bmj.com AC Bateman, SM Turner, KSA Thomas, PR … - British Medical …, 2002 - gut.bmj.com Background: Chronic pancreatitis is characterised clinically by early exocrine insufficiency, with
diabetes mellitus occurring as a late phenomenon. This is mirrored pathologically by extensive
acinar cell destruction and islet preservation. The mechanisms underlying this differential ... Cited by 28 - Related articles - BL Direct - All 8 versions
- ►ebmonline.org P Schott-Ohly, A Lgssiar, HJ Partke, M Hassan, N … - Experimental Biology and …, 2004 - SEBM Recently, we reported that zinc sulfate-enriched (25 mM) drinking water (Zn 2+ ) protected male
C57BL/6 mice from diabetes induced by multiple low doses of streptozotocin (MLD-STZ) and
that MLD-STZ activates the transcription factors nuclear factor (NF)- B and activator ... Cited by 26 - Related articles - BL Direct - All 3 versions
- ►physiology.org SS Sarang, T Yoshida, R Cadet, AS Valeras … - Physiological …, 2002 - Am Physiological Soc Oxidative injury and the resulting death of neurons is a major pathological factor involved in numerous
neurodegenerative diseases. However, the development of drugs that target this mechanism
remains limited. The goal of this study was to test a compound library of approved Food ... Cited by 25 - Related articles - BL Direct - All 4 versions
X Cao, Z Gao, CE Robert, S Greene, G Xu, W Xu, E Bell … - Diabetes, 2003 - Am Diabetes Assoc PANDER (PANcreatic DERived factor, FAM3B), a newly discovered secreted cytokine, is specifically
expressed at high levels in the islets of Langerhans of the endocrine pancreas. To evaluate the
role of PANDER in β-cell function, we investigated the effects of PANDER on rat, mouse, ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►physiology.org AM Hennige, U Ozcan, T Okada, US Jhala … - American Journal of …, 2005 - Am Physiological Soc Insulin and IGF-I activate antiapoptotic pathways via insulin receptor substrate (IRS) proteins
in most mammalian cells, including -cells. IRS-1 knockout (IRS-1KO) mice show growth
retardation, hyperinsulinemia, and hyperplastic but dysfunctional islets without ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►sciencesignaling.org WG Stetler-Stevenson - Science signaling, 2008 - stkemag.highwire.org Abstract: Over the past 20 years, the tissue inhibitors of metalloproteinases (TIMPs) have been
implicated in direct regulation of cell growth and apoptosis. However, the mechanisms of these
effects have been controversial. Recent work by several laboratories has identified ... Cited by 24 - Related articles - All 12 versions
DJ Brown, B Lin, M Chwa, SR Atilano, DW Kim, MC … - Mol Vis, 2004 - molvis.org Purpose: Keratoconus is a non-inflammatory thinning disorder of the corneal stroma.
Recently, we showed that these corneas contain inducible nitric oxide synthase and an accumulation
of nitrotyrosine, representing oxidative damage from peroxynitrite. Previously, we ... Cited by 18 - Related articles - Cached - All 3 versions
