- ►endojournals.org DG Hardie - Endocrinology, 2003 - Endocrine Soc All cells must maintain a high ratio of cellular ATP:ADP to survive. Because of the adenylate kinase
reaction (2ADP ATP + AMP), AMP rises whenever the ATP:ADP ratio falls, and a high cellular
ratio of AMP:ATP is a signal that the energy status of the cell is compromised. The AMP- ... Cited by 343 - Related articles - BL Direct - All 6 versions
H Zong, JM Ren, LH Young, M Pypaert, J … - Proceedings of the …, 2002 - National Acad Sciences Mitochondrial biogenesis is a critical adaptation to chronic energy deprivation, yet the signaling
mechanisms responsible for this response are poorly understood. To examine the role of
AMP-activated protein kinase (AMPK), an evolutionarily conserved fuel sensor, in ... Cited by 324 - Related articles - BL Direct - All 12 versions
DG Hardie, SA Hawley - Bioessays, 2001 - voh.chem.ucla.edu Summary The AMP-activated protein kinase cascade is a sensor of cellular energy charge, and
its existence provides strong support for the energy charge hypothesis first proposed by Daniel
Atkinson in the 1960s. The system is activated in an ultrasensitive manner by cellular ... Cited by 319 - Related articles - View as HTML - BL Direct - All 3 versions
- ►nih.gov JW Scott, SA Hawley, KA Green, M Anis, G … - Journal of Clinical …, 2004 - Am Soc Clin Investig CBS domains are defined as sequence motifs that occur in several different proteins in all kingdoms
of life. Although thought to be regulatory, their exact functions have been unknown.
However, their importance was underlined by findings that mutations in conserved ... Cited by 279 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org N Musi, MF Hirshman, J Nygren, M Svanfeldt, P … - Diabetes, 2002 - Am Diabetes Assoc Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing
hepatic glucose production and increasing glucose disposal in skeletal muscle; however, the
molecular site of metformin action is not well understood. AMP-activated protein kinase ( ... Cited by 235 - Related articles - BL Direct - All 4 versions
- ►nih.gov B Viollet, F Andreelli, SB Jørgensen, C … - Journal of Clinical …, 2003 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid
metabolism. To better understand the physiological role of AMPK, we generated a knockout mouse
model in which the AMPKα2 catalytic subunit gene was inactivated. AMPKα2 –/– mice ... Cited by 207 - Related articles - BL Direct - All 11 versions
SH Koo, L Flechner, L Qi, X Zhang, RA Screaton, S … - Nature, 2005 - topstitch.cornell.edu Glucose homeostasis is regulated systemically by hormones such as insulin and glucagon, and
at the cellular level by energy status. Glucagon enhances glucose output from the liver during
fasting by stimulating the transcription of gluconeogenic genes via the cyclic ... Cited by 180 - Related articles - View as HTML - BL Direct - All 21 versions
- ►nih.gov YC Long, JR Zierath - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake and
lipid oxidation to produce energy, while turning off energy-consuming processes ... Cited by 166 - Related articles - BL Direct - All 9 versions
- ►ahajournals.org MC Towler, DG Hardie - Circulation research, 2007 - Am Heart Assoc The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that
is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused
by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose ... Cited by 164 - Related articles - All 7 versions
- ►nih.gov H Satoh, MTA Nguyen, PDG Miles, T … - Journal of Clinical …, 2004 - Am Soc Clin Investig We investigated the chronic in vivo effect of resistin on insulin sensitivity and glucose metabolism
by overexpressing resistin protein in male Wistar rats using intravenous administration of an
adenovirus encoding mouse resistin. After 7 days of elevated resistin levels at a ... Cited by 159 - Related articles - BL Direct - All 7 versions
