- ►ucsf.edu [PDF] GA Francis, E Fayard, F Picard, J Auwerx - Annual review of physiology, 2003 - Annual Reviews ▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological
sensors, enabling the organism to quickly adapt to environmental changes by
inducing the appropriate metabolic genes and pathways. Ligands for these ... Cited by 258 - Related articles - BL Direct - All 7 versions
- ►nih.gov RK Semple, VKK Chatterjee, SO'Rahilly - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The nuclear receptor family of PPARs was named for the ability of the original
member to induce hepatic peroxisome proliferation in mice in response to
xenobiotic stimuli. However, studies on the action and structure of the 3 ... Cited by 243 - Related articles - BL Direct - All 10 versions
- ►endojournals.org C Knouff, J Auwerx - Endocrine Reviews, 2004 - Endocrine Soc The peroxisome proliferator-activated receptor (PPAR ) is a prototypical member
of the nuclear receptor superfamily and integrates the control of energy, lipid,
and glucose homeostasis. PPAR can bind a variety of small lipophilic ... Cited by 146 - Related articles - All 5 versions
- ►daegu.ac.kr [PDF] S Kersten - European journal of pharmacology, 2002 - Elsevier The peroxisome proliferator activated receptors (PPARs) are a group of
ligand-activated transcription factors that govern numerous biological
processes, including energy metabolism, cell proliferation, and ... Cited by 86 - Related articles - All 7 versions
- ►physiology.org NK LeBrasseur, M Kelly, TS Tsao, SR … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Thiazolidinediones (TZDs) are insulin-sensitizing agents used in the treatment
of type 2 diabetes. A widely held view is that their action is secondary to
transcriptional events that occur when TZDs bind to the nuclear receptor ... Cited by 70 - Related articles - BL Direct - All 3 versions
C Dello Russo, V Gavrilyuk, G Weinberg, A … - Journal of Biological Chemistry, 2003 - ASBMB Activation of peroxisome proliferator-activated receptors (PPARs) can regulate
brain physiology and provide protection in models of neurological disease;
however, neither their exact targets nor mechanisms of action in brain are ... Cited by 69 - Related articles - BL Direct - All 4 versions
OS Gardner, BJ Dewar, HS Earp, JM Samet, … - Journal of Biological Chemistry, 2003 - ASBMB Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone
receptors that function as ligand-activated transcription factors regulating
lipid metabolism and homeostasis. In addition to their ability to regulate ... Cited by 63 - Related articles - BL Direct - All 5 versions
A Szanto, V Narkar, Q Shen, IP Uray, PJA … - Cell Death & Differentiation, 2004 - nature.com Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription
factors that regulate many aspects of metazoan life. A class of nuclear
receptors requires RXR as heterodimerization partner for their function. ... Cited by 62 - Related articles - All 4 versions
C Fürnsinn, W Waldhäusl - Diabetologia, 2002 - Springer To unravel the molecular mechanisms and the causal chain of how
thiazolidinediones (TZDs) affect glu- cose homeostasis, it is helpful to analyse
their direct influence on isolated specimens of fat, muscle, and liver in ... Cited by 56 - Related articles - BL Direct - All 3 versions
- ►endojournals.org C Bouche, S Serdy, CR Kahn, AB Goldfine - Endocrine reviews, 2004 - Endocrine Soc Type 2 diabetes is a complex disorder with diminished insulin secretion and
insulin action contributing to the hyperglycemia and wide range of metabolic
defects that underlie the disease. The contribution of glucose metabolic ... Cited by 53 - Related articles - BL Direct - All 6 versions
