- ►fafp.org [PDF] RA DeFronzo - Medical Clinics of North America, 2004 - Elsevier A discussion of the pathogenesis of type 2 diabetes mellitus must start with a
review of mechanisms involved in the maintenance of normal glucose homeostasis
in the basal or postabsorptive state (10–12 h overnight fast) and ... Cited by 692 - Related articles - BL Direct - All 5 versions
- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, R … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and
pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable
abnormality is insulin resistance in skeletal muscle. Impaired ... Cited by 663 - Related articles - BL Direct - All 15 versions
F Foufelle, P Ferré - BIOCHEMICAL JOURNAL-LONDON-, 2002 - bj.portlandpress.com The regulation of hepatic glucose metabolism has a key role in whole-body energy
metabolism, since the liver is able to store (glycogen synthesis, lipogenesis)
and to produce (glycogenolysis, gluconeogenesis) glucose. These pathways ... Cited by 220 - Related articles - View as HTML - BL Direct - All 9 versions
D Eberle, B Hegarty, P Bossard, P Ferre, F … - Biochimie, 2004 - Elsevier Sterol regulatory element binding proteins (SREBPs) are a family of
transcription factors that regulate lipid homeostasis by controlling the
expression of a range of enzymes required for endogenous cholesterol, fatty ... Cited by 185 - Related articles - All 3 versions
- ►jlr.org AD Attie, RM Krauss, MP Gray-Keller, A … - The Journal of Lipid Research, 2002 - ASBMB Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human
tissues and is required for the biosynthesis of oleate (18:1) and palmitoleate
(16:1). These monounsaturated fatty acids are the major components of ... Cited by 122 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org K Bouzakri, M Roques, P Gual, S Espinosa, F … - Diabetes, 2003 - Am Diabetes Assoc To understand better the defects in the proximal steps of insulin signaling
during type 2 diabetes, we used differentiated human skeletal muscle cells in
primary culture. When compared with cells from control subjects, myotubes ... Cited by 98 - Related articles - BL Direct - All 4 versions
- ►nih.gov VK Yechoor, ME Patti, R Saccone, CR Kahn - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences Metabolic abnormalities underlying diabetes are primarily the result of the lack
of adequate insulin action and the associated changes in protein phosphorylation
and gene expression. To define the full set of alterations in gene ... Cited by 96 - Related articles - BL Direct - All 10 versions
GD Tan, BA Fielding, JM Currie, SM … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: We investigated the effects of rosiglitazone on NEFA
and triglyceride metabolism in type 2 diabetes. Methods: In a double-blind,
placebo-con- trolled, cross-over study of rosiglitazone in diet-treated ... Cited by 85 - Related articles - All 2 versions
C Sewter, D Berger, RV Considine, G Medina, J … - Diabetes, 2002 - Am Diabetes Assoc Sterol regulatory element binding protein (SREBP)-1 is a transcription factor
with important roles in the control of fatty acid metabolism and adipogenesis.
Little information is available regarding the expression of this molecule ... Cited by 85 - Related articles - BL Direct - All 5 versions
C Debard, M Laville, V Berbe, E Loizon, C … - Diabetologia, 2004 - Springer Aims/hypothesis. Defective oxidation of long-chain fatty acids is a feature of
insulin resistance and Type 2 diabetes. Our aim was to compare the expression
levels of the genes encoding the major proteins and enzymes of this pathway ... Cited by 82 - Related articles - BL Direct - All 4 versions
