- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & …, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle and
impaired insulin secretion. Considerable evidence also implicates deranged adipocyte metabolism
and altered fat topography in the pathogenesis of glucose intolerance in T2DM. 1) Fat ... Cited by 245 - Related articles - All 4 versions
M Stumvoll, H Häring - Diabetes, 2002 - Am Diabetes Assoc Peroxisome proliferator-activated receptor (PPAR)-γ is a transcription factor with a key role in
adipocyte differentiation. The Ala allele of the common Pro12Ala polymorphism in the isoform
PPAR-γ2 is associated with reduced risk for type 2 diabetes. The effect on the individual ... Cited by 187 - Related articles - BL Direct - All 5 versions
JG Eriksson, V Lindi, M Uusitupa, TJ Forsén, M Laakso, … - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetes is known to be associated with a small body size at birth. Body size at birth is
an indicator of the intrauterine environment. There is also a well-established association between
the peroxisome proliferator-activated receptor (PPAR)-γ2 gene and type 2 diabetes. We ... Cited by 111 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org VI Lindi, MIJ Uusitupa, J Lindström, A Louheranta, JG … - Diabetes, 2002 - Am Diabetes Assoc The association of the Pro12Ala polymorphism of the PPAR-γ2 gene with the incidence of type
2 diabetes was investigated in 522 subjects with impaired glucose tolerance (IGT) participating
in the Finnish Diabetes Prevention Study. Subjects were randomized to either an ... Cited by 108 - Related articles - BL Direct - All 7 versions
KL Houseknecht, BM Cole, PJ Steele - Domestic Animal Endocrinology, 2002 - Elsevier Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of a class of nuclear
hormone receptors intimately involved in the regulation of expression of myriad genes that regulate
energy metabolism, cell differentiation, apoptosis and inflammation. Although originally ... Cited by 103 - Related articles - BL Direct - All 7 versions
- ►physiology.org MI McCarthy, P Froguel - American Journal of Physiology- …, 2002 - Am Physiological Soc The appreciation that individual susceptibility to type 2 diabetes (T2D) and related components
of the dysmetabolic syndrome has a strong inherited component provides a coherent framework
within which to develop a molecular understanding of the pathogenesis of T2D. This ... Cited by 64 - Related articles - BL Direct - All 4 versions
JB Buse, CJ Rubin, R Frederich, K Viraswami-Appanna … - Clinical therapeutics, 2005 - Elsevier This was a randomized, double-blind, placebo-controlled, parallel-group, multicenter, 24-week
monotherapy study in drug-naive, type 2 diabetes patients with inadequate glycemic control.
Men and women aged 18 to 70 years with a body mass index ≤41 kg/m 2 and serum ... Cited by 65 - Related articles - All 6 versions
RA DeFronzo - International Journal of Clinical Practice, 2004 - interscience.wiley.com Type 2 diabetes is characterized by insulin resistance and impaired insulin secretion. Considerable
evidence implicates altered fat topography and defects in adipocyte metabolism in the pathogenesis
of type 2 diabetes. In individuals who develop type 2 diabetes, fat cells tend to be ... Cited by 54 - Related articles - BL Direct - All 4 versions
A Doney, B Fischer, D Frew, A Cumming, D Flavell… - BMC genetics, 2002 - biomedcentral.com We have genotyped a large population with type 2 diabetes (n = 1107), two populations of
non-diabetics from Glasgow (n = 186) and Dundee (n = 254) and also a healthy group undergoing
physical training (n = 148) and investigated the association of genotype with body mass ... Cited by 46 - Related articles - Cached - All 13 versions
J Matsui, Y Terauchi, N Kubota, I Takamoto, K Eto, T … - Diabetes, 2004 - Am Diabetes Assoc Heterozygous peroxisome proliferator–activated receptor-γ (PPAR-γ)-deficient (PPARγ +/− )
mice were protected from high-fat diet–induced insulin resistance. To determine the impact of
systemic reduction of PPAR-γ activity on β-cell function, we investigated insulin secretion ... Cited by 42 - Related articles - BL Direct - All 4 versions
