- ►nih.gov HJ Cordell, DG Clayton - The American Journal of Human Genetics, 2002 - Elsevier A stepwise logistic-regression procedure is proposed for evaluation of the relative importance
of variants at different sites within a small genetic region. By fitting statistical models with main
effects, rather than modeling the full haplotype effects, we generate tests, with few ... Cited by 269 - Related articles - BL Direct - All 11 versions
- ►nih.gov NJ Cox, B Wapelhorst, VA Morrison, L Johnson, L … - The American Journal of …, 2001 - Elsevier Type 1 diabetes (T1D) is a genetically complex disorder of glucose homeostasis that results
from the autoimmune destruction of the insulin-secreting cells of the pancreas. Two previous
whole-genome scans for linkage to T1D in 187 and 356 families containing affected sib ... Cited by 238 - Related articles - BL Direct - All 12 versions
- ►oxfordjournals.org F Cucca, R Lampis, M Congia, E Angius, S … - Human Molecular …, 2001 - Oxford Univ Press In human type 1 diabetes (T1D) and in its murine model, the major histocompatibility complex
(MHC) class II molecules, human leukocyte antigens (HLA)-DQ and -DR and their murine
orthologues, IA and IE, are the major genetic determinants. In this report, we have ranked ... Cited by 102 - Related articles - BL Direct - All 7 versions
S Johansson, BA Lie, JA Todd, F Pociot, J Nerup, A … - Genes and immunity, 2003 - nature.com Susceptibility to, and protection against development of type 1 diabetes (T1D) are primarily associated
with the highly polymorphic exon 2 sequences of the HLA class II genes: DQB1, DQA1 and
DRB1. However, several studies have also suggested that additional genes in the HLA ... Cited by 61 - Related articles - BL Direct - All 6 versions
AM Valdes, HA Erlich, JA Noble - Human immunology, 2005 - Elsevier Alleles of human leukocyte antigen (HLA) class II genes are well known to affect susceptibility
to type 1 diabetes (T1D), but less is known about the contribution of HLA class I alleles to T1D
susceptibility. In this study, molecular genotyping was performed at the HLA-B and HLA-C ... Cited by 36 - Related articles - All 3 versions
TL Bugawan, W Klitz, M Alejandrino, J Ching, A … - Tissue …, 2002 - interscience.wiley.com Abstract: The genetic predisposition to type 1 diabetes among Filipinos was examined by
PCR/SSOP HLA class I and II typing of 90 patients and 94 general population controls. The
HLA-DRB1, DQB1, and the A, B, and C loci were typed using the reverse SSO probe line- ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org SS Rich, P Concannon - Diabetes, 2002 - Am Diabetes Assoc There is substantial interest in the identification of genes underlying susceptibility to complex
human diseases because of the potential utility of such genes in disease prediction or
therapy. Type 1 diabetes is an example of one such disorder and is presumed to arise ... Cited by 33 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org H Erlich, AM Valdes, J Noble, JA Carlson, M Varney, P … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—A number of susceptible, neutral, and protective DR-DQ haplotypes have been
identified, and a statistically significant hierarchy of type 1 diabetes risk has been
established. The most susceptible haplotypes are the DRB1*0301-DQA1*0501-DQB1* ... Cited by 32 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org TD Cruz, AM Valdes, A Santiago, T Frazer de Llado, LJ … - Diabetes, 2004 - Am Diabetes Assoc Genetic associations between type 1 diabetes and alleles at the HLA class II locus DPB1 have
been previously reported. Observed associations could be due to variation in the DPB1 locus
itself or to linkage disequilibrium (LD) between DPB1 alleles and other susceptibility loci. ... Cited by 17 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org C Motzo, D Contu, HJ Cordell, R Lampis, M Congia, … - Diabetes, 2004 - Am Diabetes Assoc There is still uncertainty concerning the joint action of the two established type 1 diabetes susceptibility
loci, the HLA class II DQB1 and DRB1 genes (IDDM1) and the insulin gene (INS) promoter
(IDDM2). Some previous studies reported independence, whereas others suggested ... Cited by 15 - Related articles - BL Direct - All 4 versions
