SI Itani, NB Ruderman, F Schmieder, G Boden - Diabetes, 2002 - Am Diabetes Assoc The possibility that lipid-induced insulin resistance in human muscle is related
to alterations in diacylglycerol (DAG)/protein kinase C (PKC) signaling was
investigated in normal volunteers during euglycemic-hyperinsulinemic ... Cited by 522 - Related articles - BL Direct - All 4 versions
S Oyadomari, M Mori - Cell Death & Differentiation, 2003 - nature.com Endoplasmic reticulum (ER) is the site of synthesis and folding of secretory
proteins. Perturbations of ER homeostasis affect protein folding and cause ER
stress. ER can sense the stress and respond to it through translational ... Cited by 386 - Related articles - BL Direct - All 4 versions
S Oyadomari, E Araki, M Mori - Apoptosis, 2002 - Springer Apoptotic cell death in pancreatic β -cells is involved in the pathogenesis of
diabetes. Signals from death recep- tors and DNA damage have been widely
accepted as be- ing triggers of apoptosis in β -cells. Recent studies ... Cited by 217 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure.
Apoptosis is probably the main form of β-cell death in both forms of the
disease. It has been suggested that the mechanisms leading to nutrient- and ... Cited by 171 - Related articles - BL Direct - All 10 versions
AK Cardozo, H Heimberg, Y Heremans, R Leeman … - Journal of Biological Chemistry, 2001 - ASBMB Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic
-cells. Cytokines, such as interleukin-1 and interferon- , are putative
mediators of immune-induced -cell death and, under in vitro conditions, ... Cited by 158 - Related articles - BL Direct - All 4 versions
MY Donath, J Størling, K Maedler, T Mandrup … - Journal of Molecular Medicine, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes
mellitus, leading to absolute or relative insulin deficiency. β-cell death in
type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes ... Cited by 145 - Related articles - BL Direct - All 3 versions
S Frigerio, T Junt, B Lu, C Gerard, U Zumsteg, … - Nature medicine, 2002 - nature.com T cell−mediated loss of insulin-secreting cells in the islets of Langerhans is
the hallmark of type 1 diabetes. The molecular basis for the directed migration
of autoreactive T cells leading to insulitis is presently unknown. Here we ... Cited by 134 - Related articles - BL Direct - All 3 versions
- ►endojournals.org I Kharroubi, L Ladriere, AK Cardozo, Z … - Endocrinology, 2004 - Endocrine Soc Apoptosis is probably the main form of ß-cell death in both type 1 diabetes
mellitus (T1DM) and T2DM. In T1DM, cytokines contribute to ß-cell destruction
through nuclear factor- B (NF- B) activation. Previous studies suggested ... Cited by 134 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org H Heimberg, Y Heremans, C Jobin, R Leemans, … - Diabetes, 2001 - Am Diabetes Assoc Cytokine-induced β-cell death is an important event in the pathogenesis of type
1 diabetes. The transcription factor nuclear factor-κB (NF-κB) is activated by
interleukin-1β (IL-1β), and its activity promotes the expression of ... Cited by 129 - Related articles - BL Direct - All 4 versions
I Kharroubi, J Rasschaert, DL Eizirik, M Cnop - Biochemical and Biophysical Research …, 2003 - Elsevier Pancreatic β cell dysfunction is an early and crucial pathogenic factor in the
development of type 2 diabetes. Free fatty acids (FFA) and adipokines released
from adipose tissues lead to both the development of insulin resistance and ... Cited by 132 - Related articles - All 6 versions
