- ►ucsf.edu [PDF] ME Wilson, D Scheel, MS German - Mechanisms of development, 2003 - Elsevier The specialized endocrine and exocrine cells of the pancreas originally derive
from a pool of apparently identical cells in the early gut endoderm. Serial
changes in their gene expression program, controlled by a hierarchy of ... Cited by 189 - Related articles - All 8 versions
J Jensen - Developmental Dynamics, 2004 - interscience.wiley.com The intensity of research on pancreatic development has increased markedly in
the past 5 years, primarily for two reasons: we now know that the
insulin-producing -cells normally arise from an endodermally derived, ... Cited by 176 - Related articles - BL Direct - All 5 versions
S Fre, M Huyghe, P Mourikis, S Robine, D … - Nature, 2005 - nature.com The Notch signalling pathway plays a crucial role in specifying cellular fates
in metazoan development by regulating communication between adjacent cells 1, 2
. Correlative studies suggested an involvement of Notch in intestinal ... Cited by 153 - Related articles - BL Direct - All 6 versions
- ►endojournals.org JF Habener, DM Kemp, MK Thomas - Endocrinology, 2005 - Endocrine Soc Considerable progress has been made in the understanding of the sequential
activation of signal transduction pathways and the expression of transcription
factors during pancreas development. Much of this understanding has been ... Cited by 146 - Related articles - All 7 versions
- ►genopole.fr [PDF] LC Murtaugh, DA Melton - Annual review of cell and developmental biology, 2003 - Annual Reviews ▪ Abstract Type I diabetes results from the autoimmune-mediated destruction of
pancreatic beta (β) cells, which regulate blood sugar levels by secretion of
insulin. Recent clinical data suggest that the disease could be cured if an ... Cited by 118 - Related articles - BL Direct - All 6 versions
M Jenny, C Uhl, C Roche, I Duluc, V … - The EMBO Journal, 2002 - pubmedcentral.nih.gov Endocrine cells of the pancreas and the gastrointestinal tract derive from
multipotent endodermal stem cells. We have shown previously that the basic
helix– loop–helix (bHLH) transcription factor neurogenin3 (ngn3) is ... Cited by 113 - Related articles - BL Direct - All 5 versions
JM Servitja, J Ferrer - Diabetologia, 2004 - Springer Transcription factors provide the genetic instructions that drive pancreatic
development and enable mature beta cells to function properly. To understand
fully how this is accomplished, it is necessary to unravel the regulatory ... Cited by 107 - Related articles - BL Direct - All 4 versions
- ►slas.ac.cn [PDF] X Xu, J D'Hoker, G Stange, S Bonné, N De … - Cell, 2008 - Elsevier Novel strategies in diabetes therapy would obviously benefit from the use of
beta (β) cell stem/progenitor cells. However, whether or not adult β cell
progenitors exist is one of the most controversial issues in today's ... Cited by 101 - Related articles - All 9 versions
- ►endojournals.org SE Schonhoff, M Giel-Moloney, AB Leiter - Endocrinology, 2004 - Endocrine Soc For over 30 yr, it has been known that enteroendocrine cells derive from common
precursor cells in the intestinal crypts. Until recently, relatively little was
understood about the events that result in commitment to endocrine ... Cited by 75 - Related articles - BL Direct - All 4 versions
- ►endojournals.org V Bolos, J Grego-Bessa, JL de la Pompa - Endocrine reviews, 2007 - Endocrine Soc Notch is an evolutionarily conserved local cell signaling mechanism that
participates in a variety of cellular processes: cell fate specification,
differentiation, proliferation, apoptosis, adhesion, epithelial-mesenchymal ... Cited by 73 - Related articles - BL Direct - All 5 versions
