S Frame, P Cohen - BIOCHEMICAL JOURNAL-LONDON-, 2001 - bj.portlandpress.com Identified originally as a regulator of glycogen metabolism, glycogen synthase kinase-3
(GSK3) is now a well-established component of the Wnt signalling pathway, which is essential
for setting up the entire body pattern during embryonic development. It may also play ... Cited by 633 - Related articles - View as HTML - BL Direct - All 6 versions
A Martinez, A Castro, I Dorronsoro, M … - Medicinal Research …, 2002 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 122 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org RJ Gum, LL Gaede, SL Koterski, M Heindel, JE Clampit … - Diabetes, 2003 - Am Diabetes Assoc Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin receptor (IR) signal
transduction and a drug target for treatment of type 2 diabetes. Using PTP1B antisense oligonucleotides
(ASOs), effects of decreased PTP1B levels on insulin signaling in diabetic ob/ob mice ... Cited by 110 - Related articles - BL Direct - All 6 versions
P Cohen - European Journal of Biochemistry, 2001 - interscience.wiley.com The reversible phosphorylation of proteins regulates almost all aspects of cell life, while abnormal
phosphorylation is a cause or consequence of many diseases. Mutations in particular protein
kinases and phosphatases gives rise to a number of disorders and many naturally ... Cited by 110 - Related articles - BL Direct - All 2 versions
DB Ring, KW Johnson, EJ Henriksen, JM Nuss, D Goff, … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance plays a central role in the development of type 2 diabetes, but the precise defects
in insulin action remain to be elucidated. Glycogen synthase kinase 3 (GSK-3) can negatively
regulate several aspects of insulin signaling, and elevated levels of GSK-3 have been ... Cited by 104 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org GW Cline, K Johnson, W Regittnig, P Perret, E Tozzo, L … - Diabetes, 2002 - Am Diabetes Assoc Defects in liver and muscle glycogen synthesis are major factors contributing to postprandrial
hyperglycemia in patients with type 2 diabetes. Therefore, activation of glycogen synthase through
inhibition of glycogen synthase kinase (GSK)-3 represents a potential new therapeutic ... Cited by 101 - Related articles - BL Direct - All 4 versions
AS Wagman, KW Johnson, DE … - Current pharmaceutical …, 2004 - ingentaconnect.com Abstract: Originally identified as a modulator of glycogen metabolism, glycogen synthase
kinase-3 (GSK3) is now understood to play an important regulatory role in a variety of pathways
including initiation of protein synthesis, cell proliferation, cell differentiation, apoptosis, ... Cited by 77 - Related articles - BL Direct - All 5 versions
AK Srivastava, MZ Mehdi - Diabetic Medicine, 2005 - montreal-diabetes-research-center. … Compounds of the trace element vanadium exert various insulin-like effects in in vitro and in
vivo systems. These include their ability to improve glucose homeostasis and insulin resistance
in animal models of Type 1 and Type 2 dia- betes mellitus. In addition to animal studies, ... Cited by 61 - Related articles - View as HTML - BL Direct - All 5 versions
- ►physiology.org EJ Henriksen, TR Kinnick, MK Teachey, … - American Journal of …, 2003 - Am Physiological Soc A role for elevated glycogen synthase kinase-3 (GSK-3) activity in the multifactorial etiology of
insulin resistance is now emerging. However, the utility of specific GSK-3 inhibition in modulating
insulin resistance of skeletal muscle glucose transport is not yet fully understood. ... Cited by 57 - Related articles - BL Direct - All 5 versions
- ►physiology.org BB Dokken, JA Sloniger, EJ … - American Journal of …, 2005 - Am Physiological Soc Glycogen synthase kinase-3 (GSK3) has been implicated in the multifactorial etiology of skeletal
muscle insulin resistance in animal models and in human type 2 diabetic subjects. However,
the potential molecular mechanisms involved are not yet fully understood. Therefore, we ... Cited by 31 - Related articles - All 4 versions
