- ►leptipro.org [PDF] C Bjorbaek, BB Kahn - Recent progress in hormone research, 2004 - Endocrine Soc The discovery of leptin in 1994 has led to astonishing advances in understanding the regulation of
energy balance in rodents and humans. The demonstration of leptin receptors in hypothalamic regions
known to play critical roles in ... Cited by 223 - Related articles - BL Direct - All 5 versions
- ►nih.gov P Cohen, C Zhao, X Cai, JM Montez, SC … - Journal of Clinical …, 2001 - Am Soc Clin Investig Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is
indistinguishable from that of leptin deficient ob/ob mice. ObR is expressed in many tissues,
including brain, and the relative ... Cited by 215 - Related articles - BL Direct - All 9 versions
G Frühbeck - Biochemical Journal, 2006 - pubmedcentral.nih.gov Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of members
of the long-chain helical cytokine family. It is mainly produced by adipocytes in proportion to fat
size stores, and was originally ... Cited by 204 - Related articles - BL Direct - All 8 versions
- ►leptipro.org [PDF] G Sweeney - Cellular signalling, 2002 - Elsevier The identification of leptin as the product of the obesity (ob) gene has been followed by extensive
research identifying a wide spectrum of physiological effects elicited by this adipose-derived
hormone. These effects are mediated ... Cited by 177 - Related articles - All 10 versions
- ►fasebj.org RB Ceddia, HA Koistinen, JR Zierath, G Sweeney - The FASEB Journal, 2002 - FASEB Obesity is commonly associated with the development of insulin resistance and diabetes in humans and
rodents. Insulin resistance and diabetes are observed in lipoatrophic individuals or rodent models
of lipoatrophy. Here we focus on ... Cited by 140 - Related articles - BL Direct - All 4 versions
- ►jlr.org FB Kraemer, WJ Shen - The Journal of Lipid Research, 2002 - ASBMB Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing
triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid
and water soluble substrates. HSL ... Cited by 116 - Related articles - BL Direct - All 5 versions
- ►koki.hu [PDF] K Hegyi, K Fülöp, K Kovács, S Tóth, A Falus - Cell Biology International, 2004 - Elsevier Leptin is a multifunctional cytokine and hormone that primarily acts in the hypothalamus and plays a
key role in the regulation of food intake and energy expenditure. In addition, it has direct effects
on many cell types on the ... Cited by 106 - Related articles - All 5 versions
SJ Yeaman - Biochemical Journal, 2004 - pubmedcentral.nih.gov Although described initially as an intracellular adipocyte-specific triacylglycerol lipase, it is
now clear that HSL (hormone-sensitive lipase) is expressed in multiple tissues and plays a number of
roles in lipid metabolism, ... Cited by 99 - Related articles - BL Direct - All 8 versions
J Beltowski - Atherosclerosis, 2006 - Elsevier Leptin, a 167-amino acid peptide hormone produced by white adipose tissue, is primarily involved in
the regulation of food intake and energy expenditure. Leptin receptors are expressed in many tissues
including the cardiovascular ... Cited by 92 - Related articles - All 18 versions
M Faraj, HL Lu, K Cianflone - Biochemistry and Cell Biology, 2004 - article.pubs.nrc-cnrc.gc.ca Abstract: That obesity is associated with insulin resistance and type II diabetes mellitus is well
accepted. Overloading of white adipose tissue beyond its storage capacity leads to lipid disorders
in non-adipose tissues, namely ... Cited by 78 - Related articles - BL Direct - All 7 versions
