DE Kelley, J He, EV Menshikova, VB Ritov - Diabetes, 2002 - Am Diabetes Assoc Skeletal muscle is strongly dependent on oxidative phosphorylation for energy production. Because
the insulin resistance of skeletal muscle in type 2 diabetes and obesity entails dysregulation
of the oxidation of both carbohydrate and lipid fuels, the current study was undertaken to ... Cited by 533 - Related articles - BL Direct - All 4 versions
VB Ritov, EV Menshikova, J He, RE Ferrell, BH … - Diabetes, 2005 - Am Diabetes Assoc The current study addresses a novel hypothesis of subcellular distribution of mitochondrial dysfunction
in skeletal muscle in type 2 diabetes. Vastus lateralis muscle was obtained by percutaneous
biopsy from 11 volunteers with type 2 diabetes; 12 age-, sex-, and weight-matched obese ... Cited by 194 - Related articles - All 6 versions
- ►physiology.org EV Menshikova, VB Ritov, FGS Toledo, … - American Journal of …, 2005 - Am Physiological Soc The current study was undertaken to address responsiveness of skeletal muscle mitochondrial
electron transport chain (ETC) activity to weight loss (WL) and exercise in overweight or
obese, sedentary volunteers. Fourteen middle-aged participants (7 male/7 female) had ... Cited by 52 - Related articles - All 4 versions
- ►endojournals.org C Bouche, S Serdy, CR Kahn, AB Goldfine - Endocrine reviews, 2004 - Endocrine Soc Type 2 diabetes is a complex disorder with diminished insulin secretion and insulin action contributing
to the hyperglycemia and wide range of metabolic defects that underlie the disease. The contribution
of glucose metabolic pathways per se in the pathogenesis of the disease remains ... Cited by 53 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org FGS Toledo, EV Menshikova, VB Ritov, K Azuma, Z … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE— Reduced mitochondrial capacity in skeletal muscle occurs in type 2 diabetic patients
and in those at increased risk for this disorder, but the extent to which mitochondrial dysfunction
in type 2 diabetic patients is remediable by physical activity and weight loss intervention ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►nih.gov EV Menshikova, VB Ritov, L Fairfull, RE … - … of Gerontology Series …, 2006 - Geron Soc America Skeletal muscle mitochondria are implicated with age-related loss of function and insulin
resistance. We examined the effects of exercise on skeletal muscle mitochondria in older (age
= 67.3 ± 0.6 years) men (n = 5) and women (n = 3). Similar increases in (p <.01) ... Cited by 45 - Related articles - BL Direct - All 4 versions
PP Dzeja, A Terzic, B Wieringa - Molecular and cellular biochemistry, 2004 - Springer To assess the significance of energy supply routes in cellular energetic homeostasis, net phosphoryl
fluxes catalyzed by crea- tine kinase (CK), adenylate kinase (AK) and glycolytic enzymes were
quantified using 18O-phosphoryl labeling. Diaphragm muscle from double ... Cited by 27 - Related articles - BL Direct - All 7 versions
- ►physiology.org EV Menshikova, VB Ritov, RE Ferrell, K … - Journal of Applied …, 2007 - Am Physiological Soc There are fewer mitochondria and a reduced oxidative capacity in skeletal muscle in obesity.
Moderate-intensity physical activity combined with weight loss increase oxidative enzyme activity
in obese sedentary adults; however, this adaptation occurs without a significant increase ... Cited by 22 - Related articles - BL Direct - All 5 versions
FGS Toledo, EV Menshikova, K Azuma, Z Radiková, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— In obesity and type 2 diabetes, exercise combined with weight loss increases
skeletal muscle mitochondrial capacity. It remains unclear whether mitochondrial capacity increases
because of weight loss, improvements in insulin resistance, or physical training. In this ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►physiology.org HA Petersen, PT Fueger, DP Bracy, DH … - American Journal of …, 2003 - Am Physiological Soc The aim of this study was to determine barriers limiting muscle glucose uptake (MGU) during
increased glucose flux created by raising blood glucose in the presence of fixed insulin. The
determinants of the maximal velocity (V max ) of MGU in muscles of different fiber types ... Cited by 17 - Related articles - BL Direct - All 3 versions
