- ►nih.gov K Maedler, P Sergeev, F Ris, J Oberholzer, … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to
pancreatic β cells, causing impaired insulin secretion. IL-1β is a
proinflammatory cytokine acting during the autoimmune process of type 1 ... Cited by 324 - Related articles - BL Direct - All 7 versions
- ►endojournals.org EJ Abraham, CA Leech, JC Lin, H Zulewski, … - Endocrinology, 2002 - Endocrine Soc Glucagon-like peptide-1 (GLP-1) is an intestinal incretin hormone, derived from
the processing of proglucagon, that exerts insulinotropic actions on
insulin-producing pancreatic islet ß-cells. Recently GLP-1 was shown to ... Cited by 236 - Related articles - BL Direct - All 4 versions
RP Robertson - Journal of Biological Chemistry, 2004 - ASBMB Glucose in chronic excess causes toxic effects on structure and function of
organs, including the pancreatic islet. Multiple biochemical pathways and
mechanisms of action for glucose toxicity have been suggested. These ... Cited by 222 - Related articles - BL Direct - All 6 versions
- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of β cell compensation for insulin resistance, ... Cited by 196 - Related articles - BL Direct - All 7 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty
acids (FFAs) together with hyperglycemia are synergistic in causing islet
ß-cell damage because high glucose inhibits fat oxidation and consequently ... Cited by 173 - Related articles - BL Direct - All 5 versions
K Maedler, J Oberholzer, P Bucher, GA … - Diabetes, 2003 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
monounsaturated fatty acids at different glucose concentrations on human ... Cited by 149 - Related articles - BL Direct - All 5 versions
MY Donath, J Størling, K Maedler, T Mandrup … - Journal of Molecular Medicine, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes
mellitus, leading to absolute or relative insulin deficiency. β-cell death in
type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes ... Cited by 145 - Related articles - BL Direct - All 3 versions
- ►physiology.org B Rolin, MO Larsen, CF Gotfredsen, CF … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc NN2211 is a long-acting, metabolically stable glucagon-like peptide-1 (GLP-1)
derivative designed for once daily administration in humans. NN2211 dose
dependently reduced the glycemic levels in ob/ob mice, with ... Cited by 129 - Related articles - BL Direct - All 4 versions
MY Donath, PA Halban - Diabetologia, 2004 - Springer Increasing evidence indicates that decreased functional beta-cell mass is the
hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or
relative insu- lin insufficiency in both conditions. In this For Debate, we ... Cited by 123 - Related articles - BL Direct - All 6 versions
J Buteau, W El-Assaad, CJ Rhodes, L … - Diabetologia, 2004 - Springer Aims/hypothesis. We have provided evidence that gluca- gon-like peptide-1, a
potential therapeutic agent in the treatment of diabetes, activates
phosphatidylinositol-3 kinase/protein kinase B signalling in the pancreatic ... Cited by 113 - Related articles - BL Direct - All 4 versions
