- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for
causing insulin resistance and pancreatic ß-cell failure and the precise
sequence of events leading to the development of type 2 diabetes are not ... Cited by 514 - Related articles - BL Direct - All 6 versions
BB Lowell, GI Shulman - Science, 2005 - sciencemag.org Type 2 diabetes is the most common metabolic disease in the world. In the United
States, it is the leading cause of blindness, end-stage renal disease, and
nontraumatic loss of limb, with associated health care costs estimated to ... Cited by 506 - Related articles - All 6 versions
MD Brand, C Affourtit, TC Esteves, K Green, … - Free Radical Biology and Medicine, 2004 - Elsevier Mitochondria are potent producers of cellular superoxide, from complexes I and
III of the electron transport chain, and mitochondrial superoxide production is
a major cause of the cellular oxidative damage that may underlie ... Cited by 266 - Related articles - All 6 versions
P Rorsman, E Renström - Diabetologia, 2003 - Springer Glucose-induced insulin secretion in response to a step increase in blood
glucose concentrations follows a bi- phasic time course consisting of a rapid
and transient first phase followed by a slowly developing and sus- tained ... Cited by 205 - Related articles - BL Direct - All 3 versions
G Mattiasson, M Shamloo, G Gido, K Mathi, G … - Nature medicine, 2003 - ncbi.nlm.nih.gov Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the
role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA
array analysis to identify inducible neuroprotective genes, we found that ... Cited by 196 - Related articles - BL Direct - All 5 versions
- ►nih.gov S Krauss, CY Zhang, L Scorrano, LT Dalgaard, … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Failure to secrete adequate amounts of insulin in response to increasing
concentrations of glucose is an important feature of type 2 diabetes. The
mechanism for loss of glucose responsiveness is unknown. Uncoupling protein ... Cited by 192 - Related articles - BL Direct - All 11 versions
MD Brand, TC Esteves - Cell Metabolism, 2005 - Elsevier Uncoupling proteins (UCPs) have become prominent in the fields of thermogenesis,
obesity, diabetes, and free radical biology following the discovery of a family
of novel UCPs and have recently started to make an impact in the areas of ... Cited by 179 - Related articles - All 10 versions
L Bordone, MC Motta, F Picard, A Robinson, … - PLoS Biology, 2006 - biology.plosjournals.org Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower
organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and
the insulin/IGF-1 pathway has been reported. Here we investigate such a ... Cited by 138 - Related articles - Cached - BL Direct - All 13 versions
- ►physiology.org G Argyropoulos, ME Harper - Journal of Applied Physiology, 2002 - Am Physiological Soc Energy balance in animals is a metabolic state that exists when total body
energy expenditure equals dietary energy intake. Energy expenditure, or
thermogenesis, can be subcategorized into groups of obligatory and ... Cited by 129 - Related articles - BL Direct - All 5 versions
S Cadenas, KS Echtay, JA Harper, MB … - Journal of Biological Chemistry, 2002 - ASBMB The ability of native uncoupling protein-3 (UCP3) to uncouple mitochondrial
oxidative phosphorylation is controversial. We measured the expression level of
UCP3 and the proton conductance of skeletal muscle mitochondria isolated ... Cited by 125 - Related articles - BL Direct - All 5 versions
