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Scholar Results 1 - 10 of about 37 citing Frias: Decreased susceptibility to fatty acid–induced peripheral tissue insulin resistance.... (0.09 sec) 

Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin


UB Pajvani, X Du, TP Combs, AH Berg, MW … - Journal of Biological Chemistry, 2003 - ASBMB
Acrp30/adiponectin is an adipocyte-specific secretory protein that has recently
been implicated as a mediator of systemic insulin sensitivity with liver and
muscle as target organs. Acrp30 is found as two forms in serum, as a lower ...
Cited by 494 - Related articles - BL Direct - All 4 versions

Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting …

- jbc.org
A Xu, KW Chan, RLC Hoo, Y Wang, KCB Tan, … - Journal of Biological Chemistry, 2005 - ASBMB
The antidiabetic hormone adiponectin circulates in blood as several oligomeric
complexes, and the ratios between them are critical in determining insulin
sensitivity. In this study we investigated the role of testosterone in ...
Cited by 177 - Related articles - All 5 versions

Dose-response effect of elevated plasma free fatty acid on insulin signaling

- diabetesjournals.org
R Belfort, L Mandarino, S Kashyap, K Wirfel, … - Diabetes, 2005 - Am Diabetes Assoc
The dose-response relationship between elevated plasma free fatty acid (FFA)
levels and impaired insulin-mediated glucose disposal and insulin signaling was
examined in 21 lean, healthy, normal glucose-tolerant subjects. Following a ...
Cited by 85 - Related articles - All 5 versions

Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of …


BD Hegarty, GJ Cooney, EW Kraegen, SM … - Diabetes, 2002 - Am Diabetes Assoc
In humans and animal models, increased lipid content of skeletal muscle is
strongly associated with insulin resistance. However, it is unclear whether this
accumulation is due to increased uptake or reduced utilization of fatty ...
Cited by 77 - Related articles - BL Direct - All 5 versions

Mechanism of amino acid-induced skeletal muscle insulin resistance in humans


M Krebs, M Krssak, E Bernroider, C … - Diabetes, 2002 - Am Diabetes Assoc
Plasma concentrations of amino acids are frequently elevated in
insulin-resistant states, and a protein-enriched diet can impair glucose
metabolism. This study examined effects of short-term plasma amino acid ...
Cited by 60 - Related articles - BL Direct - All 5 versions

Effects of free fatty acids on glucose uptake and utilization in healthy women


CJ Homko, P Cheung, G Boden - Diabetes, 2003 - Am Diabetes Assoc
To study effects of sex on free fatty acid (FFA)-induced insulin resistance, we
have examined the effects of acute elevations of plasma FFA levels on
insulin-stimulated total body glucose uptake in nine healthy young women. ...
Cited by 43 - Related articles - BL Direct - All 5 versions

Insulin resistance: sex matters


B Mittendorfer - Current Opinion in Clinical Nutrition & Metabolic Care, 2005 - journals.lww.com
Purpose of review This review summarizes recent advances in our understanding of
the differences between the sexes in relation to insulin resistance. Alterations
in the body's sensitivity to insulin cause a series of metabolic ...
Cited by 41 - Related articles - All 4 versions

Normal insulin sensitivity and IMCL content in overweight humans are associated with higher …

- physiology.org
G Perseghin, P Scifo, M Danna, A Battezzati, … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc
Intramyocellular lipid (IMCL) storage is considered a local marker of whole body
insulin resistance; because increments of body weight are supposed to impair
insulin sensitivity, this study was designed to assess IMCL content, lipid ...
Cited by 39 - Related articles - BL Direct - All 3 versions

Free fatty acids, insulin resistance, and pregnancy


E Sivan, G Boden - Current Diabetes Reports, 2003 - Springer
Introduction Free fatty acids (FFAs) are important oxidative fuels for many body
tissues, including the heart, skeletal muscle, and liver. Their physiologic role
becomes particularly prominent during periods of starvation, prolonged ...
Cited by 34 - Related articles - BL Direct - All 2 versions

Female Rats Do Not Exhibit Free Fatty Acid–Induced Insulin Resistance


A Hevener, D Reichart, A Janez, J Olefsky - Diabetes, 2002 - Am Diabetes Assoc
It is well described that excessive lipid metabolism can cause insulin
resistance in both animals and humans, and this has been implicated as a
causative factor in the development of insulin resistance and type 2 ...
Cited by 31 - Related articles - BL Direct - All 6 versions


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