M Bajaj, S Suraamornkul, T Pratipanawatr, LJ Hardies, … - Diabetes, 2003 - Am Diabetes Assoc The effect of pioglitazone on splanchnic glucose uptake (SGU), endogenous glucose production
(EGP), and hepatic fat content was studied in 14 type 2 diabetic patients (age 50 ± 2 years, BMI
29.4 ± 1.1 kg/m 2 , HbA 1c 7.8 ± 0.4%). Hepatic fat content (magnetic resonance ... Cited by 167 - Related articles - BL Direct - All 4 versions
- ►jbc.org Y Minokoshi, CR Kahn, BB Kahn - Journal of Biological Chemistry, 2003 - ASBMB The prevalence of type 2 diabetes mellitus is growing worldwide. Most forms of type 2 diabetes
are polygenic with complex inheritance patterns strongly influenced by environmental
factors. The specific gene defects are unknown, but they affect both insulin action and ... Cited by 85 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Krssak, A Brehm, E Bernroider, C Anderwald, P … - Diabetes, 2004 - Am Diabetes Assoc Decreased skeletal muscle glucose disposal and increased endogenous glucose production
(EGP) contribute to postprandial hyperglycemia in type 2 diabetes, but the contribution of hepatic
glycogen metabolism remains uncertain. Hepatic glycogen metabolism and EGP were ... Cited by 56 - Related articles - BL Direct - All 4 versions
- ►physiology.org R Basu, B Di Camillo, G Toffolo, A Basu, P … - American Journal of …, 2003 - Am Physiological Soc Numerous studies have used the dual-tracer method to assess postprandial glucose
metabolism. The present experiments were undertaken to determine whether the marked tracer
nonsteady state that occurs with the dual-tracer approach after food ingestion introduces ... Cited by 46 - Related articles - BL Direct - All 3 versions
- ►nih.gov K Kotani, OD Peroni, Y Minokoshi, O Boss, … - Journal of Clinical …, 2004 - Am Soc Clin Investig A critical defect in type 2 diabetes is impaired insulin-stimulated glucose transport and metabolism
in muscle and adipocytes. To understand the metabolic adaptations this elicits, we generated
mice with targeted disruption of the GLUT4 glucose transporter in both adipocytes and ... Cited by 39 - Related articles - BL Direct - All 9 versions
P Shah, A Vella, A Basu, R Basu, A Adkins, WF … - Diabetes, 2002 - Am Diabetes Assoc The present study sought to determine whether elevated plasma free fatty acids (FFAs) alter
the ability of insulin and glucose to regulate splanchnic as well as muscle glucose
metabolism. To do so, FFAs were increased in 10 subjects to ∼1 mmol/l by an 8-h ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►physiology.org P Singhal, A Caumo, PE Carey, C Cobelli … - American Journal of …, 2002 - Am Physiological Soc The extent and time course of suppression of endogenous glucose production (EGP) in type
2 diabetes after a mixed meal have been determined using a new tracer methodology. Groups
of age-, sex-, and weight-matched normal controls (n = 8) and diet-controlled type 2 ... Cited by 33 - Related articles - BL Direct - All 5 versions
J Radziuk, S Pye - Diabetologia, 2002 - Springer The rate of endogenous glucose production (EGP) is important in understanding the pathophysiology
of Type II (non-insulin-dependent) diabetes mellitus, the aetiology of its complications, and the
identification of potential therapeutic targets. A great deal of effort has therefore been ... Cited by 34 - Related articles - BL Direct - All 4 versions
MS Rendell, L Jovanovic - Metabolism, 2006 - Elsevier In healthy individuals, blood glucose levels in the fasting state are maintained by the continuous
basal-level insulin secretion. After a meal, the rise in postprandial glucose (PPG) is controlled
by the rapid pancreatic release of insulin, stimulated by both glucose and the intestinal ... Cited by 30 - Related articles - All 12 versions
