TS Kern, RL Engerman - Diabetes, 2001 - Am Diabetes Assoc Effects of aminoguanidine and aspirin on the development of retinopathy have
been examined in 5-year studies of diabetic dogs. Either agent was administered
daily in doses of 20–25 mg · kg −1 · day −1 . Because severity of ... Cited by 164 - Related articles - BL Direct - All 5 versions
TW Gardner, DA Antonetti, AJ Barber, KF … - Survey of ophthalmology, 2002 - Elsevier Retinal microvascular dysfunction in diabetes is a major component of diabetic
retinopathy. This review highlights recent observations regarding the cellular
anatomy that contributes to the blood–retinal barrier and its breakdown, ... Cited by 124 - Related articles - All 6 versions
S Yamagishi, T Imaizumi - Current pharmaceutical design, 2005 - ingentaconnect.com Abstract: Diabetic vascular complication is a leading cause of end-stage renal
failure, acquired blindness, a variety of neuropathies and accelerated
atherosclerosis, which could account for disabilities and high mortality ... Cited by 123 - Related articles - All 3 versions
- ►diabetesjournals.org G Romeo, WH Liu, V Asnaghi, TS Kern, M … - Diabetes, 2002 - Am Diabetes Assoc To reconstruct the events that may contribute to the accelerated death of
retinal vascular cells in diabetes, we investigated in situ and in vitro the
activation of nuclear factor-κB (NF-κB), which is triggered by cellular ... Cited by 123 - Related articles - BL Direct - All 4 versions
M Lorenzi, C Gerhardinger - Diabetologia, 2001 - Springer Important knowledge has been gained during the last decade on how to delay the
onset and progression of diabetic retinopathy by primary treatment of the un-
derlying diabetic state. The value of tight glycaemic control, strongly ... Cited by 98 - Related articles - BL Direct - All 3 versions
JL Wilkinson-Berka - Current pharmaceutical design, 2004 - ingentaconnect.com Abstract: The pathogenetic agents involved in the development of diabetic
retinopathy are diverse. In the setting of hyperglycaemia and retinal hypoxia a
number of vasoactive factors may interact to promote pathology in a variety ... Cited by 66 - Related articles - BL Direct - All 5 versions
J Zhang, C Gerhardinger, M Lorenzi - Diabetes, 2002 - Am Diabetes Assoc Diabetic retinal microangiopathy is characterized by increased permeability,
leukostasis, microthrombosis, and apoptosis of capillary cells, all of which
could be caused or compounded by activation of complement. In this study, ... Cited by 48 - Related articles - BL Direct - All 4 versions
- ►nih.gov - Free from Publisher RA Kowluru, S Odenbach - British Journal of Ophthalmology, 2004 - bjo.bmj.com Results: High glucose increased IL-1β expression by 60% compared with cells
incubated in 5 mM glucose (p<0.05). Incubation of cells with IL-1β increased NO
levels by about 80% and activated NF-κB by 40%. In the same cells ... Cited by 36 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org M Artwohl, WF Graier, M Roden, M Bischof, A … - Diabetes, 2003 - Am Diabetes Assoc This study compares the effects of LDL glycated either in vitro (LDL iv ) or in
vivo in diabetic patients (LDL D ) on apoptosis, proliferation, and associated
protein expression in cultured human umbilical vein endothelial cells. At ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org TS Kern, CM Miller, Y Du, L Zheng, S Mohr, … - Diabetes, 2007 - Am Diabetes Assoc Pharmacologic treatment of diabetic retinopathy via eyedrops could have
advantages but has not been successful to date. We explored the effect of
topical Nepafenac, an anti-inflammatory drug known to reach the retina when ... Cited by 35 - Related articles - BL Direct - All 4 versions
