- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for causing insulin resistance
and pancreatic ß-cell failure and the precise sequence of events leading to the development
of type 2 diabetes are not yet fully understood. Abnormalities of triglyceride storage and ... Cited by 525 - Related articles - BL Direct - All 6 versions
EA Oral, V Simha, E Ruiz, A Andewelt, A … - The New England …, 2002 - nejm.highwire.org Results During treatment with recombinant leptin, the serum leptin level increased from a mean
(±SE) of 1.3±0.3 ng per milliliter to 11.1±2.5 ng per milliliter (0.1±0.02 to 0.9±0.2 nmol per
milliliter). The absolute decrease in the glycosylated hemoglobin value was 1.9 percent ... Cited by 498 - Related articles - BL Direct - All 9 versions
PJ Havel - Diabetes, 2004 - Am Diabetes Assoc Hormones produced by adipose tissue play a critical role in the regulation of energy intake, energy
expenditure, and lipid and carbohydrate metabolism. This review will address the biology,
actions, and regulation of three adipocyte hormones—leptin, acylation stimulating protein ... Cited by 341 - Related articles - BL Direct - All 7 versions
- ►mapleleafmedical.com [PDF] JP Bastard, M Caron, H Vidal, V Jan, M Auclair, C … - The Lancet, 2002 - Elsevier Patients' fat contained a higher proportion of small adipocytes than control fat, together with lower
mRNA concentrations of the adipogenic differentiation factors CCAAT-enhancer binding protein
(C/EBP) β and α, peroxisome proliferator-activated receptor (PPAR) γ, and the 1c isoform ... Cited by 275 - Related articles - BL Direct - All 7 versions
- ►kosen21.org [PDF] MW Schwartz, D Porte Jr - Science, 2005 - sciencemag.org Recent evidence suggests a key role for the brain in the control of both body fat content and glucose
metabolism. Neuronal systems that regulate energy intake, energy expenditure, and endogenous
glucose production sense and respond to input from hormonal and nutrient-related ... Cited by 268 - Related articles - All 12 versions
H Mori, R Hanada, T Hanada, D Aki, R Mashima, H … - Nature …, 2004 - cmgm.stanford.edu Leptin is an adipocyte-derived hormone that plays a key role in energy homeostasis, yet resistance
to leptin is a feature of most cases of obesity in humans and rodents. In vitro analysis suggested
that the suppressor of cytokine signaling-3 (Socs3) is a negative-feedback regulator of ... Cited by 198 - Related articles - BL Direct - All 6 versions
- ►unam.mx [PDF] DE Cummings, MW Schwartz - Annual Review of Medicine, 2003 - Annual Reviews Obesity has become a leading public health concern. Over 1 billion people are now overweight
or obese, and the prevalence of these conditions is rising rapidly. Remarkable new insights into
the mechanisms that control body weight are providing an increasingly detailed ... Cited by 193 - Related articles - BL Direct - All 7 versions
- ►sallyosborne.com [PDF] JE Schaffer - Current opinion in lipidology, 2003 - journals.lww.com Recent findings: Excess lipid accumulation in non-adipose tissues may arise in the setting of
high plasma free fatty acids or triglycerides. Alternatively, lipid overload results from mismatch
between free fatty acid import and utilization. Evidence from human studies and animal ... Cited by 197 - Related articles - BL Direct - All 8 versions
- ►alfediam.org [PDF] M Guerre-Millo - Diabetes and Metabolism, 2004 - Elsevier It is now recognized that the white adipose tissue (WAT) produces a variety of bioactive
peptides, collectively termed “adipokines”. Alteration of WAT mass in obesity or lipoatrophy, affects
the production of most adipose secreted factors. Since both conditions are associated ... Cited by 170 - Related articles - BL Direct - All 10 versions
RS Ahima, SY Osei - Physiology & behavior, 2004 - Elsevier A connection between the brain and regulation of body weight was first postulated, based on
the observation that tumors encroaching on the base of the brain caused voracious appetite,
morbid obesity, hypogonadism and other hormonal abnormalities [65]. This so-called ... Cited by 143 - Related articles - All 3 versions
