A Cheng, N Dubé, F Gu, ML Tremblay - European Journal of Biochemistry, 2002 - interscience.wiley.com Insulin is the principal regulatory hormone involved in the tight regulation of
fuel metabolism. In response to blood glucose levels, it is secreted by the β
cells of the pancreas and exerts its effects by binding to cell surface ... Cited by 108 - Related articles - BL Direct - All 3 versions
- ►nih.gov N Patel, A Rudich, ZA Khayat, R Garg, A Klip - Molecular and Cellular Biology, 2003 - Am Soc Microbiol Insulin stimulates glucose uptake by recruiting glucose transporter 4 (GLUT4)
from an intracellular pool to the cell surface through a mechanism that is
dependent on phosphatidylinositol (PI) 3-kinase (PI3-K) and cortical actin ... Cited by 53 - Related articles - BL Direct - All 13 versions
- ►jlr.org P Valet, G Tavernier, I Castan-Laurell, JS … - The Journal of Lipid Research, 2002 - ASBMB The World Health Organization has recognized obesity as a health problem of
pandemic proportions. Recent work led to major breakthroughs in the
understanding of the molecular basis of adipose tissue development with the ... Cited by 42 - Related articles - BL Direct - All 7 versions
R Suzuki, K Tobe, M Aoyama, A Inoue, K … - Journal of Biological Chemistry, 2004 - ASBMB We previously reported that insulin receptor substrate-2 (IRS-2)-deficient mice
develop diabetes as a result of insulin resistance in the liver and failure of
-cell hyperplasia. In this study we introduced the IRS-2 gene specifically ... Cited by 39 - Related articles - BL Direct - All 4 versions
R Shivakrupa, D Linnekin - Cellular signalling, 2005 - Elsevier SCF induces autophosphorylation of Kit and activates a variety of signaling
components including Jnks, Erks, PI 3 Kinase, the JAK-Stat pathway and members
of the Src family. Previously we showed that Lyn is activated at multiple ... Cited by 23 - Related articles - All 3 versions
K Cianflone - Current pharmaceutical design, 2003 - ingentaconnect.com Abstract: Triacylglycerol storage in adipose tissue is mediated by a host of
transporters, enzymes and binding proteins. Additionally, several hormones (both
autocrine and endocrine) are known to interact with cell surface receptors ... Cited by 9 - Related articles - BL Direct - All 3 versions
P Antibody - millipore.com Background Insulin receptor substrate (IRS) molecules are key mediators in
insulin signaling and play a central role in maintaining basic cellular
functions such as growth, survival, and metabolism. They act as docking ... Related articles - View as HTML - All 4 versions