AW Stitt, AJ Jenkins, ME Cooper - eid, 2002 - Informa Pharma Science 1. Introduction 2. Biochemistry of advanced glycation end product formation in biological systems
3. Role of advanced glycation end products in cellular systems 4. Advanced glycation end products
in microangiopathy 5. Diabetes-related macroangiopathy 6. Non-vascular-related ... Cited by 89 - Related articles - All 4 versions
AW Stitt - Experimental and molecular pathology, 2003 - Elsevier Retinopathy is one of the commonest microvascular complications of diabetes and is still the
prevailing cause of registerable blindness in the working population of developed countries.
The clinicopathology of microvascular lesions and the dysregulation of an array of ... Cited by 85 - Related articles - All 5 versions
BI Hudson, LG Bucciarelli, T Wendt, T Sakaguchi, E … - Archives of Biochemistry …, 2003 - Elsevier The glycation and oxidation of proteins/lipids leads to the generation of a new class of biologically
active moieties, the advanced glycation endproducts (AGEs). Recent studies have elucidated
that carboxymethyllysine (CML) adducts of proteins/lipids are a highly prevalent AGE in ... Cited by 81 - Related articles - All 4 versions
BI Hudson, AM Schmidt - Pharmaceutical research, 2004 - Springer Received January 11, 2004; accepted March 10, 2004 At high levels as seen in diabetes, glucose
reacts with and forms adducts (advanced glycation end products; AGEs) on macromolecules
including proteins and DNA, eliciting cellular dysfunction and leading to vascular disease. ... Cited by 68 - Related articles - BL Direct - All 4 versions
K Pettersson-Fernholm, C Forsblom, BI Hudson, M … - Diabetes, 2003 - Am Diabetes Assoc The hyperglycemic milieu in diabetes results in the formation of advanced glycation end products
(AGEs) that predominantly act through specific receptors, particularly the receptor for AGEs
(RAGE). Two functional polymorphisms in the promoter of the RAGE gene (−429 T/C and ... Cited by 63 - Related articles - BL Direct - All 6 versions
HJ Huttunen, H Rauvala - Journal of internal medicine, 2004 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 68 - Related articles - BL Direct - All 5 versions
JJ Rogus, JH Warram, AS Krolewski - Diabetes, 2002 - Am Diabetes Assoc Genes play a role in many processes underlying late diabetic complications, but efforts to identify
genetic variants have produced disappointing and contradictory results. Here, we evaluate whether
the study designs and analytic methods commonly being used are optimal for finding ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►rug.nl [PDF] AJ Smit, HL Lutgers - Current medicinal chemistry, 2004 - ingentaconnect.com Abstract: Advanced glycation endproducts (AGE) are a class of compounds resulting from glycation
and oxidation of proteins, lipids or nucleic acids. Glycation is the non-enzymatic addition or insertion
of saccharide derivatives to these molecules. This leads to the formation of intermediary ... Cited by 41 - Related articles - BL Direct - All 10 versions
MP Wautier, P Massin, PJ Guillausseau, M Huijberts, … - Diabetes and Metabolism, 2003 - Elsevier Hyperglycemia is linked to vascular dysfunction in patients with diabetes mellitus, either directly
or through advanced glycation end product (AGE) formation. Experimental evidence has indicated
the possible involvement of AGEs in the genesis of vascular complications. We ... Cited by 42 - Related articles - BL Direct - All 3 versions
BI Hudson, T Wendt, LG Bucciarelli, LL Rong, … - Antioxidants & Redox …, 2005 - liebertonline.com D IABETES MELLITUS is a chronic metabolic disorder char- acterized by an inherited and/or
acquired deficiency in the production or effect of insulin. This deficiency results in an increase
in blood glucose levels, which in turn may dam- age the vasculature and other target ... Cited by 39 - Related articles - BL Direct - All 3 versions
