- ►biologists.org DG Hardie - Journal of cell science, 2004 - jcs.biologists.org The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy
status. Whenever the cellular ATP:ADP ratio falls, owing to a stress that
inhibits ATP production or increases ATP consumption, this is amplified by ... Cited by 346 - Related articles - BL Direct - All 12 versions
- ►endojournals.org DG Hardie - Endocrinology, 2003 - Endocrine Soc All cells must maintain a high ratio of cellular ATP:ADP to survive. Because of
the adenylate kinase reaction (2ADP ATP + AMP), AMP rises whenever the ATP:ADP
ratio falls, and a high cellular ratio of AMP:ATP is a signal that the ... Cited by 341 - Related articles - BL Direct - All 6 versions
DG Hardie, JW Scott, DA Pan, ER Hudson - FEBS letters, 2003 - Elsevier The AMP-activated protein kinase is a sensor of cellular energy status that is
found in all eukaryotic cells. It is activated by rising AMP and falling ATP by
a complex mechanism that results in an ultrasensitive response. The ... Cited by 267 - Related articles - All 11 versions
B Kemp, D Stapleton, D Campbell, Z Chen, S … - Biochemical Society Transactions, 2003 - bst.portlandpress.com Abbreviations used: AMPK, AMP-activated protein kinase; AMPKK, AMPK kinase;
HMGR, 3-hydroxy-3-methylglutaryl-CoA reductase; GBD, glycogen-binding domain;
AICAR, 5-amino-4-imidazolecarboxamide riboside; PFK-2, ... Cited by 216 - Related articles - Cached - BL Direct - All 9 versions
- ►ahajournals.org MC Towler, DG Hardie - Circulation research, 2007 - Am Heart Assoc The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular
energy status that is conserved in all eukaryotic cells. It is activated by
increases in the cellular AMP:ATP ratio caused by metabolic stresses that ... Cited by 164 - Related articles - All 7 versions
- ►physiology.org TKT Lam, A Carpentier, GF Lewis, G van de … - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc The associations between obesity, insulin resistance, and type 2 diabetes
mellitus are well documented. Free fatty acids (FFA), which are often elevated
in obesity, have been implicated as an important link in these ... Cited by 148 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] G da Silva Xavier, I Leclerc, A Varadi, T … - Biochemical Journal, 2003 - pubmedcentral.nih.gov AMP-activated protein kinase (AMPK) has recently been impli- cated in the
control of preproinsulin gene expression in pancreatic islet β-cells [da Silva
Xavier, Leclerc, Salt, Doiron, Hardie, Kahn and Rutter (2000) Proc. Natl. ... Cited by 144 - Related articles - BL Direct - All 9 versions
GA Rutter, GDS Xavier, I Leclerc - Biochemical Journal, 2003 - pubmedcentral.nih.gov AMPK (5 -AMP-activated protein kinase) is emerging as a meta- bolic master
switch, by which cells in both mammals and lower organisms sense and decode
changes in energy status. Changes in AMPK activity have been shown to ... Cited by 141 - Related articles - BL Direct - All 8 versions
- ►jbc.org T Kawaguchi, K Osatomi, H Yamashita, T … - Journal of Biological Chemistry, 2002 - ASBMB Carbohydrate-responsive element-binding protein (ChREBP) is a new transcription
factor that binds to the carbohydrate-responsive element of the L-type pyruvate
kinase gene (L-PK). The aim of this study was to investigate the mechanism ... Cited by 138 - Related articles - BL Direct - All 5 versions
- ►shouxi.net M Foretz, N Ancellin, F Andreelli, Y Saintillan … - Diabetes, 2005 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is a major therapeutic target for the
treatment of diabetes. We investigated the effect of a short-term overexpression
of AMPK specifically in the liver by adenovirus-mediated transfer of a gene ... Cited by 101 - Related articles - All 5 versions
