V Wallenius, K Wallenius, B Ahrén, M … - Nature medicine, 2002 - nature.com The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose
tissue and centrally in hypothalamic nuclei that regulate body composition. We
investigated the impact of loss of IL-6 on body composition in mice lacking ... Cited by 440 - Related articles - BL Direct - All 4 versions
MS Sandhu, AH Heald, JM Gibson, JK … - The Lancet, 2002 - Elsevier At 4·5 years of follow-up, 51 (8%) of 615 participants developed impaired
glucose tolerance or type-2 diabetes. After adjustment for correlates of IGF-I
and risk factors for glucose intolerance, the odds ratio for risk of ... Cited by 211 - Related articles - All 6 versions
J Frystyk - Growth hormone & IGF research, 2004 - Elsevier IGF-I is a multipotent growth factor with important actions on normal tissue
growth and regeneration. In addition, IGF-I has been suggested to have
beneficial effects on glucose homeostasis due to its glucose lowering and ... Cited by 107 - Related articles - All 5 versions
- ►endojournals.org JD Veldhuis, JN Roemmich, EJ Richmond, AD … - Endocrine reviews, 2005 - Endocrine Soc Body composition exhibits marked variations across the early human lifetime. The
precise physiological mechanisms that drive such developmental adaptations are
difficult to establish. This clinical challenge reflects an array of ... Cited by 93 - Related articles - All 4 versions
- ►shouxi.net HM Domene, SV Bengolea, AS Martinez, MG … - N Engl J Med, 2004 - nejm.org Some 80 to 85 percent of IGF-I circulates as a 150-kD ternary complex that
includes the ligand itself, IGF-binding protein 3, and an acid-labile subunit. 5
The acid-labile subunit is a glycoprotein found almost exclusively in the ... Cited by 91 - Related articles - BL Direct - All 7 versions
RIG Holt, HL Simpson, PH Sonksen - Diabetic Medicine, 2003 - interscience.wiley.com Homeostatic mechanisms normally maintain the plasma glucose concentration within
narrow limits despite major fluctuations in supply and demand. There is
increasing evidence that the growth hormone (GH)–insulin-like growth ... Cited by 86 - Related articles - BL Direct - All 5 versions
- ►endojournals.org HL Simpson, NC Jackson, F Shojaee-Moradie … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc INSULIN RESISTANCE is an important feature of type 1 diabetes. In addition to
being insulin resistant with respect to glucose metabolism (1), patients with
type 1 diabetes are also insulin resistant with respect to lipid and ... Cited by 50 - Related articles - BL Direct - All 5 versions
- ►endojournals.org K Wallenius, K Sjogren, XD Peng, S Park, V … - Endocrinology, 2001 - Endocrine Soc We have reported that liver-specific deletion of IGF-I in mice (LI-IGF-I-/-)
results in decreased circulating IGF-I and increased GH levels. In the present
study, we determined how elimination of hepatic IGF-I modifies the ... Cited by 48 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org L Persson, J Boren, AKL Robertson, V … - Arteriosclerosis, thrombosis, and vascular biology, 2004 - Am Heart Assoc Methods and Results— Complement-deficient mice were crossed with mice
deficient in both apolipoprotein E and the low-density lipoprotein receptor
(Apoe–/– LDLR–/–). The percent lesion area in the aorta at 16 ... Cited by 43 - Related articles - BL Direct - All 8 versions
AH Heald, SG Anderson, F Ivison, I Laing, JM … - Atherosclerosis, 2003 - Elsevier Inflammatory processes, marked in part by the acute phase reactant C-reactive
protein (CRP) and insulin resistance are implicated in atherogenesis. Low
insulin-like growth factor-I (IGF-I) and IGF binding protein-1 (IGFBP-1) ... Cited by 39 - Related articles - All 11 versions
