- ►diabetesjournals.org J Buteau, S Foisy, E Joly, M Prentki - Diabetes, 2003 - Am Diabetes Assoc We previously provided evidence that glucagon-like peptide 1 (GLP-1) induces
pancreatic ß-cell growth nonadditively with glucose in a phosphatidylinositol
(PI) 3-kinase- and protein kinase C -dependent manner. However, the exact ... Cited by 146 - Related articles - BL Direct - All 5 versions
A Suzuki, H Nakauchi, H Taniguchi - Diabetes, 2004 - Am Diabetes Assoc During pancreatic development, neogenesis, and regeneration, stem cells might
act as a central player to generate endocrine, acinar, and duct cells. Although
these cells are well known as pancreatic stem cells (PSCs), indisputable ... Cited by 138 - Related articles - BL Direct - All 4 versions
- ►genopole.fr [PDF] LC Murtaugh, DA Melton - Annual review of cell and developmental biology, 2003 - Annual Reviews ▪ Abstract Type I diabetes results from the autoimmune-mediated destruction of
pancreatic beta (β) cells, which regulate blood sugar levels by secretion of
insulin. Recent clinical data suggest that the disease could be cured if an ... Cited by 118 - Related articles - BL Direct - All 6 versions
- ►nih.gov T Sapir, K Shternhall, I Meivar-Levy, T … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Shortage in tissue availability from cadaver donors and the need for life-long
immunosuppression severely restrict the large-scale application of
cell-replacement therapy for diabetic patients. This study suggests the ... Cited by 97 - Related articles - All 10 versions
L Baeyens, S De Breuck, J Lardon, JK … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Transplantation of insulin- producing beta cells from
donors can cure diabetes, but they are available in insufficient quantities. In
this study, we investigated the possibility of generating insulin- ... Cited by 93 - Related articles - All 6 versions
- ►tufts.edu [PDF] LL Baggio, DJ Drucker, 2006 - Annual Reviews Type 2 diabetes is characterized by hyperglycemia resulting from insulin
resistance in the setting of inadequate β-cell compensation. Currently
available therapeutic agents lower blood glucose through multiple ... Cited by 77 - Related articles - BL Direct - All 10 versions
- ►nih.gov K Minami, M Okuno, K Miyawaki, A Okumachi, … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Although several studies have suggested that insulin-secreting cells can be
generated in vitro from cells residing in adult exocrine pancreas, neither the
origin of these cells nor their precise insulin secretory properties was ... Cited by 74 - Related articles - BL Direct - All 11 versions
- ►endojournals.org WL Suarez-Pinzon, JRT Lakey, SJ Brand, A … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Pancreatic islet transplantation is a viable treatment for type 1 diabetes, but
is limited by human donor tissue availability. The combination of epidermal
growth factor (EGF) and gastrin induces islet ß-cell neogenesis from ... Cited by 68 - Related articles - All 5 versions
- ►nih.gov L Elghazi, C Cras-Méneur, P Czernichow, R … - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences Pancreatic development is a classic example of epithelium–mesenchyme
interaction. During embryonic life, signals from the mesenchyme control the
proliferation of precursor cells within the pancreatic epithelium and their ... Cited by 65 - Related articles - BL Direct - All 11 versions
I Rooman, L Bouwens - Diabetologia, 2004 - Springer Aims/hypothesis. Increasing beta-cell mass and/or function could restore glucose
homeostasis in diabetes mellitus. Hitherto, trophic factors for beta-cell regen-
eration after toxic events have been difficult to identi- fy. We evaluated ... Cited by 63 - Related articles - BL Direct - All 4 versions
