- ►nih.gov B Viollet, F Andreelli, SB Jørgensen, C … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and
lipid metabolism. To better understand the physiological role of AMPK, we
generated a knockout mouse model in which the AMPKα2 catalytic subunit ... Cited by 205 - Related articles - BL Direct - All 11 versions
R Hyde, PM Taylor, HS Hundal - Biochemical Journal, 2003 - pubmedcentral.nih.gov Amino acid availability regulates cellular physiology by modu- lating gene
expression and signal transduction pathways. How- ever, although the signalling
intermediates between nutrient availability and altered gene expression ... Cited by 80 - Related articles - BL Direct - All 9 versions
P Newsholme, L Brennan, B Rubi, P Maechler - Clin. Sci, 2005 - cs.portlandpress.com Specific amino acids are now known to acutely and chronically regulate insulin
secretion from pancreatic β-cells in vivo and in vitro. Understanding the
molecular mechanisms by which amino acids regulate insulin secretion may ... Cited by 35 - Related articles - View as HTML - All 12 versions
- ►unige.ch [PDF] P Maechler, S Carobbio, B Rubi - International Journal of Biochemistry and Cell Biology, 2006 - Elsevier Pancreatic beta-cells are unique neuroendocrine cells displaying the peculiar
feature of responding to nutrients, principally glucose, as primary stimulus.
This requires translation of a metabolic substrate into intracellular ... Cited by 29 - Related articles - All 7 versions
MC Barber, NT Price, MT Travers - BBA-Molecular and Cell Biology of Lipids, 2005 - Elsevier Acetyl-CoA carboxylase (ACC) plays a fundamental role in fatty acid metabolism.
The reaction product, malonyl-CoA, is both an intermediate in the de novo
synthesis of long-chain fatty acids and also a substrate for distinct fatty ... Cited by 27 - Related articles - All 3 versions
S Zraika, M Dunlop, J Proietto, S … - Obesity reviews, 2002 - interscience.wiley.com The prevalence of obesity in Western society has reached epidemic proportions
and its aetiological role in the development of type 2 diabetes has made finding
an effective treatment for the condition of crucial importance. Of the many ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org R Amin, HQ Chen, M Tannous, R Gibbs, A … - Journal of Pharmacology and Experimental …, 2002 - ASPET The majority of low molecular weight G proteins undergoes a series of
post-translational modification steps, eg, isoprenylation, at their C-terminal
cysteine, which seem to be critical for the transport of the modified ... Cited by 20 - Related articles - BL Direct - All 4 versions
A Kowluru - Biochemical pharmacology, 2005 - Elsevier Protein phosphorylation constitutes one of the key signaling steps in
physiological insulin secretion. The phosphorylation status of a given protein
represents the balance of the activities of protein kinases and ... Cited by 14 - Related articles - All 4 versions
P Newsholme, K Bender, A Kiely, L Brennan - Biochemical Society Transactions, 2007 - ncbi.nlm.nih.gov In addition to the primary stimulus of glucose, specific amino acids may acutely
and chronically regulate insulin secretion from pancreatic beta-cells in vivo
and in vitro. Mitochondrial metabolism is crucial for the coupling of ... Cited by 13 - Related articles - BL Direct - All 3 versions
- ►cardiovascres.org R Palanivel, X Fang, M Park, M Eguchi, S … - Cardiovascular research, 2007 - cardiovascres.org Methods We produced fAd (consisting of high, medium and low molecular weight
oligomers) in a mammalian expression system and gAd in bacteria. These were used
to treat primary neonatal rat cardiomyocytes (up to 48 h), and we employed ... Cited by 12 - Related articles - All 7 versions
