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Scholar Results 1 - 10 of about 88 citing Deacon: Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and.... (0.18 sec) 

Biology of incretins: GLP-1 and GIP

- rh.dk [PDF] 
LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier
This review focuses on the mechanisms regulating the synthesis, secretion,
biological actions, and therapeutic relevance of the incretin peptides
glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like ...
Cited by 173 - Related articles - All 25 versions

Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions …


AM Lambeir, C Durinx, S Scharpé, I De … - Critical reviews in clinical laboratory sciences, 2003 - informahealthcare.com
Laboratory of Medical Biochemistry, University of Antwerp, Universiteitsplein 1,
Wilrijk, Belgium ... Referee: Dr. Albert Adam, Faculté de Pharmace,
Université de Montréal, 2900 Blvd. Edouard—Montpetit, CP succursale ...
Cited by 166 - Related articles - BL Direct - All 9 versions

Therapeutic strategies based on glucagon-like peptide 1

- diabetesjournals.org
CF Deacon - Diabetes, 2004 - Am Diabetes Assoc
Glucagon-like peptide (GLP)-1 is an incretin hormone with potent
glucose-dependent insulinotropic and glucagonostatic actions, trophic effects on
the pancreatic β-cells, and inhibitory effects on gastrointestinal ...
Cited by 154 - Related articles - BL Direct - All 5 versions

Incretins, insulin secretion and type 2 diabetes mellitus


T Vilsbøll, JJ Holst - Diabetologia, 2004 - Springer
When glucose is taken orally, insulin secretion is stim- ulated much more than
it is when glucose is infused intravenously so as to result in similar glucose
con- centrations. This effect, which is called the incretin ef- fect and is ...
Cited by 145 - Related articles - BL Direct - All 7 versions

Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes


DJ Drucker - eid, 2003 - informahealthcare.com
Incretins are peptide hormones, exemplified by glucose-dependent insulino-
tropic peptide and glucagon-like peptide 1 that are released from the gut in
response to nutrient ingestion and enhance glucose-stimulated insulin ...
Cited by 118 - Related articles - All 6 versions

Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular …

- diabetesjournals.org
T Hansotia, LL Baggio, D Delmeire, SA Hinke, … - Diabetes, 2004 - Am Diabetes Assoc
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1
(GLP-1) are gut-derived incretins that potentiate glucose clearance following
nutrient ingestion. Elimination of incretin receptor action in GIPR −/− ...
Cited by 110 - Related articles - BL Direct - All 13 versions

Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves …

- eje-online.org [PDF] 
MK Reimer, JJ Holst, B Ahren - European Journal of Endocrinology, 2002 - EFES
Objectives: Inhibitors of the glucagon-like peptide-1 (GLP-1)-degrading enzyme,
dipeptidyl peptidase IV (DPPIV), are being explored in the treatment of
diabetes. We examined the long-term influence of a selective, orally active ...
Cited by 107 - Related articles - BL Direct - All 9 versions

Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of …


CF Deacon, B Ahrén, JJ Holst - eid, 2004 - informahealthcare.com
Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) are of increasing
interest to both diabetologists and the pharmaceutical industry alike, as they
may become established as the next member of the oral antidiabetic class of ...
Cited by 102 - Related articles - All 7 versions

What do we know about the secretion and degradation of incretin hormones?


CF Deacon - Regulatory peptides, 2005 - Elsevier
The incretin hormones, glucose-dependent insulinotropic peptide (GIP) and
glucagon-like peptide-1 (GLP-1) are secreted from endocrine cells located in the
intestinal mucosa, and act to enhance meal-induced insulin secretion. GIP ...
Cited by 70 - Related articles - All 6 versions

Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses …

- endocrinology-journals.org [PDF] 
CF Deacon, S Wamberg, P Bie, TE Hughes, JJ … - Journal of Endocrinology, 2002 - Soc Endocrinology
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are degraded by dipeptidyl peptidase IV (DPP
IV), thereby losing insulinotropic activity. DPP IV inhibition reduces ...
Cited by 63 - Related articles - BL Direct - All 3 versions


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