- ►endojournals.org JL Evans, ID Goldfine, BA Maddux, GM Grodsky - Endocrine Reviews, 2002 - Endocrine Soc In both type 1 and type 2 diabetes, the late diabetic complications in nerve, vascular
endothelium, and kidney arise from chronic elevations of glucose and possibly other metabolites
including free fatty acids (FFA). Recent evidence suggests that common stress-activated ... Cited by 598 - Related articles - BL Direct - All 18 versions
SI Itani, NB Ruderman, F Schmieder, G Boden - Diabetes, 2002 - Am Diabetes Assoc The possibility that lipid-induced insulin resistance in human muscle is related to alterations
in diacylglycerol (DAG)/protein kinase C (PKC) signaling was investigated in normal volunteers
during euglycemic-hyperinsulinemic clamping in which plasma free fatty acid (FFA) levels ... Cited by 523 - Related articles - BL Direct - All 4 versions
- ►endojournals.org GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - Endocrine Soc The primary genetic, environmental, and metabolic factors responsible for causing insulin resistance
and pancreatic ß-cell failure and the precise sequence of events leading to the development
of type 2 diabetes are not yet fully understood. Abnormalities of triglyceride storage and ... Cited by 525 - Related articles - BL Direct - All 6 versions
G Boden, GI Shulman - European Journal of Clinical …, 2002 - interscience.wiley.com Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart, liver
and pancreas. However, chronically elevated plasma FFA appear to have pathophysiological
consequences. Elevated FFA concentrations are linked with the onset of peripheral and ... Cited by 491 - Related articles - BL Direct - All 3 versions
DE Kelley, BH Goodpaster - Diabetes Care, 2001 - Am Diabetes Assoc Recent evidence derived from four independent methods indicates that an excess triglyceride
storage within skeletal muscle is linked to insulin resistance. Potential mechanisms for this association
include apparent defects in fatty acid metabolism that are centered at the mitochondria in ... Cited by 224 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org D Tripathy, P Mohanty, S Dhindsa, T Syed, H Ghanim, … - Diabetes, 2003 - Am Diabetes Assoc To test the possible acute proinflammatory effects of fatty acids, we induced an increase in plasma
free fatty acid (FFA) concentrations after a lipid and heparin infusion for 4 h in 10 healthy
subjects. We determined the nuclear factor-κB (NF-κB) binding activity in mononuclear ... Cited by 229 - Related articles - BL Direct - All 4 versions
I Gabriely, XH Ma, XM Yang, G Atzmon, MW Rajala, AH … - Diabetes, 2002 - Am Diabetes Assoc Age-dependent changes in insulin action and body fat distribution are risk factors for the development
of type 2 diabetes. To examine whether the accumulation of visceral fat (VF) could play a direct
role in the pathophysiology of insulin resistance and type 2 diabetes, we monitored ... Cited by 194 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org HJ Kim, T Higashimori, SY Park, H Choi, J Dong, YJ … - Diabetes, 2004 - Am Diabetes Assoc The circulating level of the inflammatory cytokine interleukin (IL)-6 is elevated in various
insulin-resistant states including type 2 diabetes, obesity, cancer, and HIV-associated
lipodystrophy. To determine the role of IL-6 in the development of insulin resistance, we ... Cited by 166 - Related articles - BL Direct - All 4 versions
- ►nih.gov HC Chen, SJ Smith, Z Ladha, DR Jensen, … - Journal of Clinical …, 2002 - Am Soc Clin Investig Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes
that catalyze the final step in mammalian triglyceride synthesis. DGAT1-deficient mice are resistant
to diet-induced obesity through a mechanism involving increased energy expenditure. ... Cited by 130 - Related articles - BL Direct - All 8 versions
BD Hegarty, SM Furler, J Ye, GJ Cooney, … - Acta Physiologica …, 2003 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 122 - Related articles - BL Direct - All 4 versions
