H Vlassara, MR Palace - Journal of internal medicine, 2002 - interscience.wiley.com Bio-reactive advanced glycation endproducts (AGE) alter the structure and
function of molecules in biological systems and increase oxidative stress. These
adverse effects of both exogenous and endogenously derived AGE have been ... Cited by 279 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org A Stitt, TA Gardiner, NL Anderson, P Canning … - Diabetes, 2002 - Am Diabetes Assoc We examined the ability of pyridoxamine (PM), an inhibitor of formation of
advanced glycation end products (AGEs) and lipoxidation end products (ALEs), to
protect against diabetes-induced retinal vascular lesions. The effects of ... Cited by 178 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org TA Ciulla, AG Amador, B Zinman - Diabetes Care, 2003 - Am Diabetes Assoc Diabetic retinopathy (DR) and diabetic macular edema (DME) are leading causes of
blindness in the working-age population of most developed countries. The
increasing number of individuals with diabetes worldwide suggests that DR ... Cited by 132 - Related articles - BL Direct - All 6 versions
PJ Thornalley - Archives of Biochemistry and Biophysics, 2003 - Elsevier Aminoguanidine (AG) is a prototype therapeutic agent for the prevention of
formation of advanced glycation endproducts. It reacts rapidly with
α,β-dicarbonyl compounds such as methylglyoxal, glyoxal, and ... Cited by 123 - Related articles - All 4 versions
Y Du, CM Miller, TS Kern - Free Radical Biology and Medicine, 2003 - Elsevier Oxidative stress is believed to play a significant role in the development of
diabetic retinopathy. In this study, we have investigated the effects of
elevated glucose concentration on the production of superoxide anion by ... Cited by 99 - Related articles - All 5 versions
L Zheng, C Szabó, TS Kern - Diabetes, 2004 - Am Diabetes Assoc The current study investigated the role of poly(ADP-ribose) polymerase (PARP) in
the development of diabetic retinopathy. Activity of PARP was increased in whole
retina and in endothelial cells and pericytes of diabetic rats. ... Cited by 98 - Related articles - BL Direct - All 5 versions
- ►bmj.com [PDF] AP Adamis - British Medical Journal, 2002 - bjo.bmj.com L ast year an ARVO symposium organ- ised by Tim Kern was titled “Is diabetic
retinopathy an inflamma- tory disease?” It is a timely question. chronic
subclinical inflammation may underlie much of the vascular pathology of ... Cited by 96 - Related articles - BL Direct - All 7 versions
RN Frank - American journal of ophthalmology, 2002 - Elsevier RESULTS: Kinases transfer the terminal, “high energy,” phosphate group of
ATP to a site on a target protein, thereby activating the protein, which may be
an enzyme, cell membrane receptor, or ion transport channel. The PKC family ... Cited by 91 - Related articles - All 13 versions
RB Caldwell, M Bartoli, MA Behzadian, AEB … - Diabetes/Metabolism Reviews - interscience.wiley.com Retinal neovascularization and macular edema are central features of diabetic
retinopathy, the major cause of blindness in the developed world. Current
treatments are limited in their efficacy and are associated with ... Cited by 89 - Related articles - BL Direct - All 3 versions
