- ►physiology.org AC Newby - Physiological reviews, 2005 - Am Physiological Soc Intimal thickening, the accumulation of cells and extracellular matrix within the inner vessel
wall, is a physiological response to mechanical injury, increased wall stress, or chemical insult
(eg, atherosclerosis). If excessive, it can lead to the obstruction of blood flow and tissue ... Cited by 274 - Related articles - All 9 versions
- ►nih.gov CB Renard, F Kramer, F Johansson, N … - Journal of Clinical …, 2004 - Am Soc Clin Investig Diabetes in humans accelerates cardiovascular disease caused by atherosclerosis. The relative
contributions of hyperglycemia and dyslipidemia to atherosclerosis in patients with diabetes
are not clear, largely because there is a lack of suitable animal models. We therefore ... Cited by 91 - Related articles - BL Direct - All 8 versions
R Natarajan, RG Gerrity, JL Gu, L Lanting, L Thomas, … - Diabetologia, 2002 - Springer Diabetes is associated with significantly accelerated rates of atherosclerotic and hypertensive
cardiovas- cular diseases. The cellular and molecular mecha- nisms are still not fully
understood, mainly due to the lack of animal models that mirror the changes in human ... Cited by 62 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org N Brodala, EP Merricks, DA Bellinger, D … - … , and vascular biology, 2005 - Am Heart Assoc Methods and Results— Pigs (n=36) fed low- or high-fat chow were divided into P
gingivalis–sensitized and P gingivalis–challenged groups or P gingivalis–sensitized controls
and saline-treated controls. Pigs were sensitized with 10 9 killed P gingivalis ... Cited by 51 - Related articles - All 8 versions
MO Larsen, B Rolin - ILAR JOURNAL., 2004 - dels.nas.edu Animal models of type 1 diabetes remain essential tools for investigation of the etiology and pathogenesis
of the disease and, importantly, for the development of effective new treatments. Although a range
of well-characterized and widely used models of type 1 diabetes in rodents are cur- rently ... Cited by 38 - Related articles - View as HTML - BL Direct - All 2 versions
T Mazzone, A Chait, J Plutzky - The Lancet, 2008 - Elsevier Individuals with type 2 diabetes mellitus have increased cardiovascular disease risk compared
with those without diabetes. Treatment of the residual risk, other than blood pressure and
LDL-cholesterol control, remains important as the rate of diabetes increases worldwide. ... Cited by 37 - Related articles - All 11 versions
AV Finn, HK Gold, A Tang, DK Weber, TN … - Journal of vascular …, 2000 - content.karger.com The effects of risk modifiers such as diabetes, obesity and hypertension on vascular healing
after stent deployment are largely unknown, because of a lack of an appropriate animal model
to study. Since many inbred strains of rats expressing these phenotypes are available, we ... Cited by 34 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Passarelli, C Tang, TO McDonald, KD O'Brien, RG … - Diabetes, 2005 - Am Diabetes Assoc Abnormal HDL metabolism may contribute to the increased atherosclerosis associated with
diabetes. The ATP-binding cassette transporter A1 (ABCA1) is an atheroprotective cell protein
that mediates cholesterol transport from cells to apolipoprotein (apo) AI, the major protein ... Cited by 34 - Related articles - All 5 versions
- ►physiology.org KM Ajuwon, SK Jacobi, JL Kuske, ME … - American Journal of …, 2004 - Am Physiological Soc 3T3-L1 adipocytes express the lipopolysaccharide (LPS) receptor and respond to direct stimulation
with the antigen by increasing the expression of inflammatory mediators. Activation of this receptor
by its ligand in the macrophage causes the activation and translocation of nuclear factor- ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org JE Kanter, F Johansson, RC LeBoeuf, KE … - Circulation research, 2007 - Am Heart Assoc It is becoming increasingly clear that suboptimal blood glucose control results in adverse effects
on large blood vessels, thereby accelerating atherosclerosis and cardiovascular disease, manifested
as myocardial infarction, stroke, and peripheral vascular disease. Cardiovascular disease ... Cited by 33 - Related articles - All 8 versions
