- ►nih.gov K Maedler, P Sergeev, F Ris, J Oberholzer, … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to
pancreatic β cells, causing impaired insulin secretion. IL-1β is a
proinflammatory cytokine acting during the autoimmune process of type 1 ... Cited by 329 - Related articles - BL Direct - All 7 versions
- ►endojournals.org EJ Abraham, CA Leech, JC Lin, H Zulewski, … - Endocrinology, 2002 - Endocrine Soc Glucagon-like peptide-1 (GLP-1) is an intestinal incretin hormone, derived from
the processing of proglucagon, that exerts insulinotropic actions on
insulin-producing pancreatic islet ß-cells. Recently GLP-1 was shown to ... Cited by 238 - Related articles - BL Direct - All 4 versions
- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of β cell compensation for insulin resistance, ... Cited by 199 - Related articles - BL Direct - All 7 versions
K Maedler, J Oberholzer, P Bucher, GA … - Diabetes, 2003 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
monounsaturated fatty acids at different glucose concentrations on human ... Cited by 150 - Related articles - BL Direct - All 5 versions
MY Donath, J Størling, K Maedler, T Mandrup … - Journal of Molecular Medicine, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes
mellitus, leading to absolute or relative insulin deficiency. β-cell death in
type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes ... Cited by 145 - Related articles - BL Direct - All 3 versions
- ►jhsph.edu [PDF] CM Larsen, M Faulenbach, A Vaag, A Volund, … - The New England journal of medicine, 2007 - nejm.highwire.org Methods In this double-blind, parallel-group trial involving 70 patients with
type 2 diabetes, we randomly assigned 34 patients to receive 100 mg of anakinra
(a recombinant human interleukin-1–receptor antagonist) subcutaneously ... Cited by 144 - Related articles - BL Direct - All 12 versions
MY Donath, PA Halban - Diabetologia, 2004 - Springer Increasing evidence indicates that decreased functional beta-cell mass is the
hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or
relative insu- lin insufficiency in both conditions. In this For Debate, we ... Cited by 123 - Related articles - BL Direct - All 6 versions
H Kolb, T Mandrup-Poulsen - Diabetologia, 2005 - Springer Abstract Subclinical, low-grade systemic inflammation has been observed in
patients with type 2 diabetes and in those at increased risk of the disease.
This may be more than an epiphenomenon. Alleles of genes encoding immune/ ... Cited by 118 - Related articles - BL Direct - All 5 versions
M Kibirige, B Metcalf, R Renuka, TJ Wilkin - Diabetes Care, 2003 - Am Diabetes Assoc OBJECTIVE—Previous reports have predicted greater risk of type 1 diabetes
among people who were heavier as young children. The Accelerator Hypothesis
predicts earlier onset in heavier people, without necessarily a change in ... Cited by 101 - Related articles - BL Direct - All 6 versions
- ►pnas.org K Maedler, A Fontana, F Ris, P Sergeev, C … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences Type 2 diabetes mellitus results from an inadequate adaptation of the functional
pancreatic β cell mass in the face of insulin resistance. Changes in the
concentration of glucose play an essential role in the regulation of β ... Cited by 96 - Related articles - BL Direct - All 11 versions
