- ►uni-karlsruhe.de [PDF] G Keller - Genes & development, 2005 - genesdev.cshlp.org The discovery of mouse embryonic stem (ES) cells >20 years ago represented a
major advance in biology and experimental medicine, as it enabled the routine
manipulation of the mouse genome. Along with the capacity to induce genetic ... Cited by 373 - Related articles - BL Direct - All 12 versions
- ►colorado.edu [PDF] J Rajagopal, WJ Anderson, S Kume, OI … - Science, 2003 - sciencemag.org Despite antibody staining, we did not detect insulin 1 mRNA by reverse
transcription-polymerase chain reaction (RT-PCR) and insulin 2 mRNA detection
was weak. Multiple primers used during all five stages of the protocol (1) ... Cited by 357 - Related articles - All 5 versions
- ►nih.gov P Blyszczuk, J Czyz, G Kania, M Wagner, U … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Mouse embryonic stem (ES) cells differentiate into cells of all three primary
germ layers including endodermal cells that produce insulin in vitro. We show
that constitutive expression of Pax4 (Pax4 + ), and to a lesser extent Pdx1 ... Cited by 327 - Related articles - BL Direct - All 11 versions
- ►nih.gov M Drukker, G Katz, A Urbach, M Schuldiner, G … - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences Human embryonic stem (ES) cells are pluripotent cells that may be used in
transplantation medicine. These cells can be induced to differentiate into cells
from the three embryonic germ layers both in vivo and in vitro. To ... Cited by 296 - Related articles - BL Direct - All 9 versions
- ►physiology.org AM Wobus, KR Boheler - Physiological reviews, 2005 - Am Physiological Soc Stem cells represent natural units of embryonic development and tissue
regeneration. Embryonic stem (ES) cells, in particular, possess a nearly
unlimited self-renewal capacity and developmental potential to ... Cited by 284 - Related articles - All 7 versions
K Chadwick, L Wang, L Li, P Menendez, B … - Blood, 2003 - Am Soc Hematology Human embryonic stem cells (hESCs) randomly differentiate into multiple cell
types during embryoid body (EB) development. To date, characterization of
specific factors capable of influencing hematopoietic cell fate from hESCs ... Cited by 287 - Related articles - BL Direct - All 7 versions
K AD'Amour, AG Bang, S Eliazer, OG Kelly, … - Nature - med.upenn.edu Of paramount importance for the development of cell therapies to treat diabetes
is the production of sufficient numbers of pancreatic endocrine cells that
function similarly to primary islets. We have developed a differentiation ... Cited by 275 - Related articles - View as HTML - BL Direct - All 17 versions
- ►alphamedpress.org JK Henderson, JS Draper, HS Baillie, S … - Stem Cells, 2002 - AlphaMed Press Cell-surface antigens provide invaluable tools for the identification of cells
and for the analysis of cell differentiation. In particular, stage-specific
embryonic antigens that are developmentally regulated during early ... Cited by 254 - Related articles - BL Direct - All 8 versions
- ►mit.edu [PDF] K Hochedlinger, R Jaenisch - The New England journal of medicine, 2003 - nejm.highwire.org Nuclear cloning, also referred to as nuclear transfer or nuclear
transplantation, denotes the introduction of a nucleus from an adult donor cell
into an enucleated oocyte to generate a cloned embryo. When transferred to ... Cited by 238 - Related articles - BL Direct - All 19 versions
- ►alphamedpress.org M Richards, SP Tan, JH Tan, WK Chan, A … - Stem Cells, 2004 - AlphaMed Press Human embryonic stem (ES) cell lines that have the ability to self-renew and
differentiate into specific cell types have been established. The molecular
mechanisms for self-renewal and differentiation, however, are poorly ... Cited by 227 - Related articles - BL Direct - All 7 versions
