SM Lieberman, TP DiLorenzo - Tissue Antigens, 2003 - interscience.wiley.com Abstract: Type 1 diabetes (T1D) is an organ-specific autoimmune disease in which
the insulin-producing β cells in the pancreatic islets are selectively
eliminated. T cells specific for β-cell antigens are the mediators of this ... Cited by 60 - Related articles - BL Direct - All 5 versions
TP Di Lorenzo, M Peakman, BO Roep - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov T cell epitopes represent the molecular code words through which the adaptive
immune system communicates. In the context of a T cell-mediated autoimmune
disease such as type 1 diabetes, CD4 and CD8 T cell recognition of islet ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►nih.gov JC Hutton, GS Eisenbarth - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Diabetes has been termed the epidemic of the 21st century and over the past 50
years in Western societies has been doubling in incidence every 15 years. It
exacts a huge socioeconomic toll because of its devastating microvascular ... Cited by 28 - Related articles - BL Direct - All 7 versions
PY Arnold, AR Burton, DAA Vignali - The Journal of Immunology, 2004 - Am Assoc Immnol TCR transgenic mice are valuable tools for dissecting the role of
autoantigen-specific T cells in the pathogenesis of type 1 diabetes but are
time-consuming to generate and backcross onto congenic strains. To ... Cited by 21 - Related articles - BL Direct - All 5 versions
PN Pichurin, CR Chen, Y Nagayama, O … - Clinical and Experimental Immunology, 2004 - pubmedcentral.nih.gov Immunization with thyrotropin receptor (TSHR)-adenovirus is an effective
approach for inducing thyroid stimulating antibodies and Graves' hyperthyroidism
in BALB/c mice. In contrast, mice of the same strain vaccinated with ... Cited by 15 - Related articles - BL Direct - All 5 versions
C Panagiotopoulos, JD Trudeau, R Tan - Current Diabetes Reports, 2004 - Springer Introduction Type 1 diabetes (T1D) is an autoimmune disease that results from
destruction of insulin-producing pancreatic β cells in the islets of
Langerhans. In genetically predisposed individu- als, as-yet unidentified ... Cited by 12 - Related articles - BL Direct - All 2 versions
P Achenbach, K Kelemen, DR Wegmann, JC … - Journal of Autoimmunity, 2002 - Elsevier Phogrin (IA-2β), a major autoantigen in type 1 diabetes in man is recognized by
peripheral T cells in the nonobese diabetic (NOD) mouse. CD4 + T-cell clones
derived from immunized NOD animals elicit islet destruction in a disease ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Li, N Perez, S Karumuthil-Melethil, C Vasu - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—The pancreatic microenvironment is considered to be the primary
location of autoreactive T-cells in type 1 diabetes. Diabetogenic T-cells have
also been detected in the spleens of NOD mice. However, it is not known ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org K Kelemen, PA Gottlieb, AL Putnam, HW … - The Journal of Immunology, 2004 - Am Assoc Immnol Susceptibility to type 1A autoimmune diabetes is linked to expression of
particular MHC class II molecules, notably HLA-DQ8 in man and the orthologous IA
g7 in the nonobese diabetic mouse. In the present study, we analyzed two ... Cited by 7 - Related articles - BL Direct - All 4 versions
AR Burton, E Vincent, PY Arnold, GP Lennon, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Neither GAD- nor IA2-specific TCRs mediated T-cell islet infiltration
or diabetes even though T-cells developed in these Rg mice and responded to
their cognate epitope. IA2β/phogrin and insulin-specific Rg T-cells ... Cited by 6 - Related articles - BL Direct - All 4 versions
