- ►endojournals.org JM Barker, KJ Barriga, L Yu, D Miao, HA Erlich, … - Journal of Clinical …, 2004 - Endocrine Soc Diabetes Autoimmunity Study in the Young (DAISY) has followed 1972 children for islet autoimmunity
and diabetes: 837 first-degree relatives of persons with type 1 diabetes and 1135 general population
newborns identified through human leukocyte antigen (HLA) screening. During follow-up ... Cited by 102 - Related articles - BL Direct - All 6 versions
- ►endojournals.org JP Krischer, DD Cuthbertson, L Yu, T Orban, N … - Journal of Clinical …, 2003 - Endocrine Soc There were 1010 (5.9%) relatives with a single autoantibody on initial screening and 394
(2.3%) with two or more autoantibodies. GAA was more sensitive than ICA [GAA, 91% (357 of
394); ICA, 82% (324 of 394)] in the detection of multiple antibody-positive individuals. The ... Cited by 69 - Related articles - BL Direct - All 4 versions
GS Eisenbarth, H Moriyama, DT Robles, E Liu, L Yu, S … - Autoimmunity Reviews, 2002 - Elsevier Type 1 diabetes of both the NOD mouse and man is associated with autoimmunity directed against
insulin which is the only beta cell specific autoantigen identified to date. One can use autoantibodies
to insulin to predict diabetes, use insulin peptides to create insulin autoantibodies, ... Cited by 28 - Related articles - All 3 versions
BD Tait, PG Colman, G Morahan, L … - Tissue …, 2003 - interscience.wiley.com Abstract: Insulin dependent diabetes mellitus (type I DM) is caused by an autoimmune process
which culminates in destruction of pancreatic beta cells with resultant loss of insulin
production. Preceding the clinical diagnosis of type I DM is a preclinical stage ... Cited by 27 - Related articles - BL Direct - All 4 versions
V Seyfert-Margolis, TD Gisler, AL Asare, RS Wang, HM … - Diabetes, 2006 - Am Diabetes Assoc Type 1 diabetes is a chronic autoimmune disease mediated by autoreactive T-cells. Several
experimental therapies targeting T-cells are in clinical trials. To understand how these therapies
affect T-cell responses in vivo, assays that directly measure human T-cell function are ... Cited by 20 - Related articles - BL Direct - All 8 versions
AJK Williams, PJ Bingley, WPT Moore, EAM Gale - Diabetologia, 2002 - Springer Family members have an increased risk of developing Type I (insulin-dependent) diabetes
mellitus, and testing for multiple islet autoantibodies can achieve sensitive and specific identification
of those who are destined to develop the disease [1]. The European Nicotinamide ... Cited by 12 - Related articles - BL Direct - All 4 versions
JM Wenzlau, Y Liu, L Yu, O Moua, KT Fowler, S … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Sera from 224 subjects (53%) were reactive to Arg 325 probes, from 185 (44%)
to Trp 325 probes, and from 142 (34%) to Gln 325 probes. Sixty subjects reacted only with Arg
325 constructs, 31 with Trp 325 only, and 1 with Gln 325 only. The restriction to either Arg ... Cited by 12 - Related articles - All 4 versions
- ►adisonline.com [PDF] N Petrovsky, D Silva, DA Schatz - Drugs, 2002 - ingentaconnect.com Abstract Type 1 (insulin-dependent) diabetes mellitus results from selective immune- mediated
destruction of pancreatic islet β cells. Strategies to prevent or reverse the development of diabetes
can be divided into three groups, depending on whether they focus on β -cell protection, ... Cited by 10 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org A Quinn, M McInerney, D Huffman, B … - International …, 2006 - Jpn Soc Immunol Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes, and serve as
a model for type 1 diabetes (T1D) and natural autoimmunity. T cell responses to the pancreatic
islet antigen glutamic acid decarboxylase 65 (GAD65) can be detected in the spleens of ... Cited by 9 - Related articles - BL Direct - All 5 versions
D Miao, L Yu, C Tiberti, DD Cuthbertson, M Rewers, … - Journal of Autoimmunity, 2002 - Elsevier ICA512/IA-2, a tyrosine phosphatase-like protein, is one of the major autoantigens in type 1
diabetes. Following phage display characterization of ICA512 autoantigenic epitopes, we developed
fluid phase autoantibody radioimmunoassays for a series of ICA512 fragments (F1 [amino ... Cited by 6 - Related articles - BL Direct - All 6 versions
