- ►nih.gov K Maedler, P Sergeev, F Ris, J Oberholzer, … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to
pancreatic β cells, causing impaired insulin secretion. IL-1β is a
proinflammatory cytokine acting during the autoimmune process of type 1 ... Cited by 324 - Related articles - BL Direct - All 7 versions
- ►daegu.ac.kr [PDF] DL Eizirik, T Mandrup-Poulsen - Diabetologia, 2001 - Springer Apoptosis is likely to be the main form of beta-cell death in immune-mediated
diabetes mellitus in ro- dents and possibly in humans. Clarification of the
regulation of beta-cell death could indicate novel sites for therapeutic ... Cited by 320 - Related articles - BL Direct - All 6 versions
AK Cardozo, H Heimberg, Y Heremans, R Leeman … - Journal of Biological Chemistry, 2001 - ASBMB Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic
-cells. Cytokines, such as interleukin-1 and interferon- , are putative
mediators of immune-induced -cell death and, under in vitro conditions, ... Cited by 158 - Related articles - BL Direct - All 4 versions
- ►endojournals.org I Kharroubi, L Ladriere, AK Cardozo, Z … - Endocrinology, 2004 - Endocrine Soc Apoptosis is probably the main form of ß-cell death in both type 1 diabetes
mellitus (T1DM) and T2DM. In T1DM, cytokines contribute to ß-cell destruction
through nuclear factor- B (NF- B) activation. Previous studies suggested ... Cited by 134 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org H Heimberg, Y Heremans, C Jobin, R Leemans, … - Diabetes, 2001 - Am Diabetes Assoc Cytokine-induced β-cell death is an important event in the pathogenesis of type
1 diabetes. The transcription factor nuclear factor-κB (NF-κB) is activated by
interleukin-1β (IL-1β), and its activity promotes the expression of ... Cited by 129 - Related articles - BL Direct - All 4 versions
I Rakatzi, H Mueller, O Ritzeler, N Tennagels, … - Diabetologia, 2004 - Springer Aims/hypothesis. Pancreatic beta-cell apoptosis is a common feature of Type 1
and Type 2 diabetes and leptin exerts an anti-apoptotic function in these cells.
The beta-cell line INS-1 was used to test the hypothe- sis that the ... Cited by 83 - Related articles - BL Direct - All 4 versions
S Wu, YS Ko, MS Teng, YL Ko, LA Hsu, C … - Journal of molecular and cellular cardiology, 2002 - Elsevier S. Wu, Y.-S. Ko, M.-S. Teng, Y.-L. Ko, L.-A. Hsu, C. Hsueh, Y.-Y. Chou, C.-C.
Liew and Y.-S. Lee. Adriamycin-induced Cardiomyocyte and Endothelial Cell
Apoptosis: In Vitro and In Vivo Studies. Journal of Molecular and Cellular ... Cited by 58 - Related articles - BL Direct - All 8 versions
B Kutlu, MI Darville, AK Cardozo, DL Eizirik - Diabetes, 2003 - Am Diabetes Assoc Pancreatic β-cells are selectively destroyed during the course of type 1
diabetes. In the early stages of the disease, inflammatory infiltrates of
mononuclear cells, containing predominantly monocytes and T-cells, are ... Cited by 55 - Related articles - BL Direct - All 5 versions
KK Rehman, S Bertera, R Bottino, AN … - Journal of Biological Chemistry, 2003 - ASBMB We have previously demonstrated that adenoviral gene transfer of the NF-κB
inhibitor IκB to human islets results in protection from interleukin
(IL)-1β-mediated dysfunction and apoptosis. Here we report that human and ... Cited by 53 - Related articles - BL Direct - All 4 versions
- ►endojournals.org D Liu, AK Cardozo, MI Darville, DL Eizirik - Endocrinology, 2002 - Endocrine Soc Viral infections may trigger the autoimmune assault leading to type 1 diabetes
mellitus. Double-stranded RNA (dsRNA) is produced by many viruses during their
replicative cycle. The dsRNA, tested as synthetic poly(IC) (PIC), in ... Cited by 51 - Related articles - BL Direct - All 4 versions
