- ►endojournals.org V Poitout, RP Robertson - Endocrinology, 2002 - Endocrine Soc Chronic hyperglycemia and hyperlipidemia can exert deleterious effects on ß-cell function, respectively
referred to as glucotoxicity and lipotoxicity. Over time, both contribute to the progressive deterioration
of glucose homeostasis characteristic of type 2 diabetes. The mechanisms of glucotoxicity ... Cited by 329 - Related articles - BL Direct - All 4 versions
- ►pnas.org LL Listenberger, X Han, SE Lewis, S … - Proceedings of the …, 2003 - National Acad Sciences Excess lipid accumulation in non-adipose tissues is associated with insulin resistance, pancreatic
β-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the relative toxicity
of two common dietary long chain fatty acids is related to channeling of these lipids to ... Cited by 314 - Related articles - BL Direct - All 10 versions
R Lupi, F Dotta, L Marselli, S Del Guerra, M Masini, C … - Diabetes, 2002 - Am Diabetes Assoc In an effort to better understand the phenomenon of lipotoxicity in human β-cells, we evaluated
the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA) (2:1 oleate to
palmitate) on the function and survival of isolated human islets and investigated some of ... Cited by 270 - Related articles - BL Direct - All 7 versions
RP Robertson, J Harmon, POT Tran, V Poitout - Diabetes, 2004 - Am Diabetes Assoc The relentless decline in β-cell function frequently observed in type 2 diabetic patients, despite
optimal drug management, has variously been attributed to glucose toxicity and lipotoxicity. The
former theory posits hyperglycemia, an outcome of the disease, as a secondary force that ... Cited by 202 - Related articles - BL Direct - All 5 versions
- ►sallyosborne.com [PDF] JE Schaffer - Current opinion in lipidology, 2003 - journals.lww.com Recent findings: Excess lipid accumulation in non-adipose tissues may arise in the setting of
high plasma free fatty acids or triglycerides. Alternatively, lipid overload results from mismatch
between free fatty acid import and utilization. Evidence from human studies and animal ... Cited by 197 - Related articles - BL Direct - All 8 versions
- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in the pathogenesis
of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of β cell
compensation for insulin resistance, consideration is also given to the mechanisms ... Cited by 199 - Related articles - BL Direct - All 7 versions
- ►unc.edu [PDF] RA Coleman, DP Lee - Progress in Lipid Research, 2004 - Elsevier Since the pathways of glycerolipid biosynthesis were elucidated in the 1950's, considerable
knowledge has been gained about the enzymes that catalyze the lipid biosynthetic reactions
and the factors that regulate triacylglycerol biosynthesis. In the last few decades, in part ... Cited by 184 - Related articles - All 8 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R Roduit, S … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs)
together with hyperglycemia are synergistic in causing islet ß-cell damage because high glucose
inhibits fat oxidation and consequently lipid detoxification. The effects of 1–2 d culture of ... Cited by 174 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen, DL … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure. Apoptosis is probably
the main form of β-cell death in both forms of the disease. It has been suggested that the mechanisms
leading to nutrient- and cytokine-induced β-cell death in type 2 and type 1 diabetes, ... Cited by 174 - Related articles - BL Direct - All 10 versions
- ►nih.gov JD Johnson, NT Ahmed, DS Luciani, Z Han … - Journal of Clinical …, 2003 - Am Soc Clin Investig Mice with 50% Pdx1, a homeobox gene critical for pancreatic development, had worsening glucose
tolerance with age and reduced insulin release in response to glucose, KCl, and arginine from
the perfused pancreas. Surprisingly, insulin secretion in perifusion or static incubation ... Cited by 151 - Related articles - BL Direct - All 8 versions
