P Rorsman, E Renström - Diabetologia, 2003 - Springer Glucose-induced insulin secretion in response to a step increase in blood glucose concentrations
follows a bi- phasic time course consisting of a rapid and transient first phase followed by a slowly
developing and sus- tained second phase. Because Type 2 diabetes involves defects of ... Cited by 205 - Related articles - BL Direct - All 3 versions
S Göpel, Q Zhang, L Eliasson, XS Ma, J … - The Journal of …, 2004 - Physiological Soc Capacitance measurements of exocytosis were applied to functionally identified α-, β- and
δ-cells in intact mouse pancreatic islets. The maximum rate of capacitance increase in β-cells
during a depolarization to 0 mV was equivalent to 14 granules s −1 , <5% of that ... Cited by 52 - Related articles - All 7 versions
- ►nih.gov MG Pedersen, R Bertram, A Sherman - Biophysical journal, 2005 - Elsevier Insulin secretion from pancreatic β-cells is pulsatile with a period of 5–10 min and is believed
to be responsible for plasma insulin oscillations with similar frequency. To observe an overall
oscillatory insulin profile it is necessary that the insulin secretion from individual β-cells is ... Cited by 31 - Related articles - BL Direct - All 14 versions
RM Iskakov, A Kikuchi, T Okano - Journal of Controlled Release, 2002 - Elsevier Time-programmed release of macromolecular drugs was achieved by utilization of calcium-alginate
gel beads modified with coated copolymer layers. Modified calcium-alginate gel beads coated
with poly(carboxy-n-propylacrylamide-co-dimethylacrylamide) [poly(CNPAAm-co-DMAAm ... Cited by 26 - Related articles - All 6 versions
DS Luciani, S Misler, KS Polonsky - The Journal of Physiology, 2006 - Physiological Soc Exposure of pancreatic islets of Langerhans to physiological concentrations of glucose leads
to secretion of insulin in an oscillatory pattern. The oscillations in insulin secretion are associated
with oscillations in cytosolic Ca 2+ concentration ([Ca 2+ ] c ). Evidence suggests that the ... Cited by 26 - Related articles - BL Direct - All 7 versions
- ►endojournals.org RA Ritzel, JD Veldhuis, PC Butler - Journal of Clinical Endocrinology & …, 2003 - Endocrine Soc INSULIN IS SECRETED in a glucose-regulated manner (1, 2). Insulin release is pulsatile with
an interpulse interval of approximately 6 min (3, 4). In vivo insulin secretion in response to glucose
ingestion and glucose infusion is driven by amplification of insulin pulse mass with no or ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org S Srivastava, HJ Goren - Diabetes, 2003 - Am Diabetes Assoc Four hypotheses have been posited on the role of insulin in glucose-stimulated insulin
secretion; available evidence has supported insulin as being 1) essential, 2) a positive
modulator, 3) a negative modulator, or 4) not necessary. Because circulating insulin ... Cited by 19 - Related articles - BL Direct - All 4 versions
T Kanno, X Ma, S Barg, L Eliasson, J Galvanovskis, S … - Methods, 2004 - Elsevier Pancreatic β-cells arise from the pancreatic anlage of the embryonic endoderm [1 and 2]. Although
being of endodermal origin, the pancreatic β-cells share numerous features with neurones and
neuroendocrine cells. First, the major secretory product (insulin) is stored within ... Cited by 15 - Related articles - All 3 versions
- ►umich.edu [PDF] JF Dishinger - deepblue.lib.umich.edu Page 1. PARALLEL SEPARATIONS ON MICROFLUIDIC CHIPS FOR HIGH
THROUGHPUT MONITORING OF INSULIN SECRETION FROM SINGLE ISLETS
OF LANGERHANS by John F. Dishinger A dissertation submitted ... Related articles - View as HTML
