D Melloul, S Marshak, E Cerasi - Diabetologia, 2002 - Springer Insulin, synthesized by the beta cells of pancreatic is- lets, is of major physiological importance
in metabolic homeostasis. While mature insulin consists of two polypeptide chains joined by
disulphide bridges, the gene encodes for a highly conserved single chain pre- cursor, ... Cited by 170 - Related articles - BL Direct - All 3 versions
- ►nih.gov JD Johnson, NT Ahmed, DS Luciani, Z Han … - Journal of Clinical …, 2003 - Am Soc Clin Investig Mice with 50% Pdx1, a homeobox gene critical for pancreatic development, had worsening glucose
tolerance with age and reduced insulin release in response to glucose, KCl, and arginine from
the perfused pancreas. Surprisingly, insulin secretion in perifusion or static incubation ... Cited by 151 - Related articles - BL Direct - All 8 versions
DR Laybutt, M Glandt, G Xu, YB Ahn, N Trivedi, S … - Journal of Biological …, 2003 - ASBMB We have proposed that hyperglycemia-induced dedifferentiation of -cells is a critical factor for
the loss of insulin secretory function in diabetes. Here we examined the effects of the duration
of hyperglycemia on gene expression in islets of partially pancreatectomized (Px) rats. ... Cited by 69 - Related articles - BL Direct - All 4 versions
H Huang, X Tang - Laboratory Investigation, 2003 - nature.com Demand for donations to meet the requirements of pancreas or islet transplantation has prompted
the search for alternative sources of -cell replacement therapy. Earlier studies identified
nestin-positive islet-derived progenitor cells (NIPs) residing in human pancreas. In the ... Cited by 57 - Related articles - BL Direct - All 4 versions
- ►nutrition.org V Poitout, D Hagman, R Stein, I Artner, RP … - Journal of …, 2006 - Am Soc Nutrition The insulin gene is expressed almost exclusively in pancreatic ß-cells. Metabolic regulation of
insulin gene expression enables the ß-cell to maintain adequate stores of intracellular insulin
to sustain the secretory demand. Glucose is the major physiologic regulator of insulin ... Cited by 57 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org H Kaneto, Y Nakatani, T Miyatsuka, T Matsuoka, M … - Diabetes, 2005 - Am Diabetes Assoc Diabetes is the most prevalent and serious metabolic disease, and the number of diabetic patients
worldwide is increasing. The reduction of insulin biosynthesis in pancreatic β-cells is closely
associated with the onset and progression of diabetes, and thus it is important to search ... Cited by 54 - Related articles - All 6 versions
AL Mosley, JA Corbett, S Ozcan - Molecular Endocrinology, 2004 - Endocrine Soc Regulation of insulin gene expression in response to increases in blood glucose levels is essential
for maintaining normal glucose homeostasis; however, the exact mechanisms by which glucose
stimulates insulin gene transcription are not known. We have shown previously that ... Cited by 43 - Related articles - BL Direct - All 4 versions
BE Tuch, B Szymanska, M Yao, MT Tabiin, DJ Gross, S … - Gene Therapy, 2003 - nature.com An alternative approach to the treatment of type I diabetes is the use of genetically altered neoplastic
liver cells to synthesize, store and secrete insulin. To try and achieve this goal we modified a
human liver cell line, HUH7, by transfecting it with human insulin cDNA under the control ... Cited by 28 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org N Kaiser, R Nesher, MY Donath, M Fraenkel, V Behar, … - Diabetes, 2005 - Am Diabetes Assoc Type 2 diabetes is characterized by insulin resistance and progressive ß-cell failure. Deficient
insulin secretion, with increased proportions of insulin precursor molecules, is a common feature
of type 2 diabetes; this could result from inappropriate ß-cell function and/or reduced ... Cited by 26 - Related articles - BL Direct - All 6 versions
- ►endojournals.org G Leibowitz, G Uckaya, AI Oprescu, E Cerasi, DJ Gross … - Endocrinology, 2002 - Endocrine Soc UNDER PHYSIOLOGICAL CONDITIONS, the secretion and biosynthesis of insulin are
coordinated. Indeed, stimulation of insulin release is associated with a rapid and sustained increase
of proinsulin biosynthesis thus preventing the depletion of pancreatic insulin stores (1). ... Cited by 21 - Related articles - BL Direct - All 7 versions
