- ►physiology.org G Boden, P Cheung, TP Stein, K Kresge, M … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc Free fatty acids (FFA) have been shown to inhibit insulin suppression of
endogenous glucose production (EGP). To determine whether this is the result of
stimulation by FFA of gluconeogenesis (GNG) or glycogenolysis (GL) or a ... Cited by 120 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org C Anderwald, E Bernroider, M Krs̆s̆ák, H … - Diabetes, 2002 - Am Diabetes Assoc Insulin resistance is frequently associated with increased lipid content in
muscle and liver. Insulin excess stimulates tissue lipid accumulation. To
examine the effects of insulin and improved glycemia on insulin sensitivity ... Cited by 82 - Related articles - BL Direct - All 5 versions
- ►endojournals.org A Gastaldelli, Y Miyazaki, M Pettiti, M … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Visceral fat (VF) excess has been associated with decreased peripheral insulin
sensitivity and has been suggested to contribute to hepatic insulin resistance.
However, the mechanisms by which VF impacts on hepatic glucose metabolism ... Cited by 71 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org G Boden, M Laakso - Diabetes Care, 2004 - Am Diabetes Assoc Historically, type 2 diabetes was considered to revolve around a glucose-insulin
axis. The foundations for this thinking were probably laid down by two momentous
discoveries in diabetes research. According to popular legend, Oskar ... Cited by 58 - Related articles - All 5 versions
- ►endojournals.org C Bouche, S Serdy, CR Kahn, AB Goldfine - Endocrine reviews, 2004 - Endocrine Soc Type 2 diabetes is a complex disorder with diminished insulin secretion and
insulin action contributing to the hyperglycemia and wide range of metabolic
defects that underlie the disease. The contribution of glucose metabolic ... Cited by 51 - Related articles - BL Direct - All 6 versions
G Boden - Current diabetes reports, 2006 - Springer Plasma free fatty acid (FFA) levels are elevated in obesity. FFA, by causing
insulin resistance in muscle, liver, and endothelial cells, contributes to the
development of type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, ... Cited by 41 - Related articles - BL Direct - All 4 versions
P Shah, A Vella, A Basu, R Basu, A Adkins, … - Diabetes, 2002 - Am Diabetes Assoc The present study sought to determine whether elevated plasma free fatty acids
(FFAs) alter the ability of insulin and glucose to regulate splanchnic as well
as muscle glucose metabolism. To do so, FFAs were increased in 10 subjects ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►physiology.org IE Peterside, MA Selak, RA Simmons - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc Intrauterine growth retardation (IUGR) has been linked to the development of
type 2 diabetes in adulthood. We have developed an IUGR model in the rat whereby
the animals develop diabetes between 3 and 6 mo of age that is associated ... Cited by 37 - Related articles - BL Direct - All 3 versions
- ►endojournals.org A Gastaldelli, Y Miyazaki, M Pettiti, E … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc The contribution of increased gluconeogenesis (GNG) to the excessive rate of
endogenous glucose production (EGP) in type 2 diabetes (T2DM) is well
established. However, the separate effects of obesity (total body fat), ... Cited by 35 - Related articles - BL Direct - All 5 versions
E Sivan, G Boden - Current Diabetes Reports, 2003 - Springer Introduction Free fatty acids (FFAs) are important oxidative fuels for many body
tissues, including the heart, skeletal muscle, and liver. Their physiologic role
becomes particularly prominent during periods of starvation, prolonged ... Cited by 34 - Related articles - BL Direct - All 2 versions
