- ►nih.gov JD Horton, JL Goldstein, MS Brown - Journal of Clinical …, 2002 - Am Soc Clin Investig Lipid homeostasis in vertebrate cells is regulated by a family of membrane-bound transcription
factors designated sterol regulatory element–binding proteins (SREBPs). SREBPs directly activate
the expression of more than 30 genes dedicated to the synthesis and uptake of ... Cited by 1133 - Related articles - BL Direct - All 15 versions
G Marchesini, E Bugianesi, G Forlani, F Cerrelli, M … - Hepatology, 2003 - interscience.wiley.com Nonalcoholic fatty liver disease (NAFLD) has been associated with the insulin-resistance
syndrome, at present defined as the metabolic syndrome, whose limits were recently set. We
assessed the prevalence of the metabolic syndrome in 304 consecutive NAFLD patients ... Cited by 747 - Related articles - BL Direct - All 3 versions
EM Brunt - Seminars in liver disease, 2001 - thieme-connect.com Nonalcoholic steatohepatitis (NASH) is a significant form of chronic liver disease in adults and
children. The natural history of NASH ranges from indolent to end-stage liver disease. Current
studies are focusing on identification of histologic and/or clinical markers of progression. ... Cited by 635 - Related articles - BL Direct - All 10 versions
S Chitturi, S Abeygunasekera, GC Farrell, J Holmes … - Hepatology, 2002 - interscience.wiley.com Nonalcoholic steatohepatitis (NASH) is often linked with disorders that are clearly associated
with insulin resistance (IR): obesity, type 2 diabetes mellitus, and hypertriglyceridemia. We tested
the hypotheses that (1) IR is an essential requirement for the development of NASH and ... Cited by 562 - Related articles - BL Direct - All 3 versions
JD Browning, LS Szczepaniak, R Dobbins, P … - Hepatology, 2004 - interscience.wiley.com Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), its pathogenesis
and clinical significance remain poorly defined. In this study, we examined and compared the
distribution of hepatic triglyceride content (HTGC) in 2,287 subjects from a multiethnic, ... Cited by 532 - Related articles - All 3 versions
- ►nih.gov JD Browning, JD Horton - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Obesity and its associated comorbidities are among the most prevalent and challenging conditions
confronting the medical profession in the 21st century. A major metabolic consequence of obesity
is insulin resistance, which is strongly associated with the deposition of triglycerides in the ... Cited by 478 - Related articles - BL Direct - All 15 versions
K Promrat, G Lutchman, GI Uwaifo, RJ Freedman, A … - Hepatology, 2004 - hepatitis.cl Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease for which there is no
known effective therapy. A proportion of patients with NASH progress to advanced fibrosis and
cirrhosis. NASH is considered one of the clinical features of the metabolic syndrome in ... Cited by 470 - Related articles - View as HTML - All 7 versions
JM Hui, A Hodge, GC Farrell, JG Kench, A Kriketos, … - Hepatology, 2004 - interscience.wiley.com Adiponectin has antilipogenic and anti-inflammatory effects, while tumor necrosis factor
(TNF- ) reduces insulin sensitivity and has proinflammatory effects. We examined (1) the extent
to which hypoadiponectinemia and TNF- activation are features of nonalcoholic ... Cited by 470 - Related articles - All 3 versions
DE Kleiner, EM Brunt, M Van Natta, C Behling, MJ … - Hepatology, 2005 - sadieo.ucsf.edu Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in the absence
of a history of significant alcohol use or other known liver disease. Nonalcoholic steatohepa-
titis (NASH) is the progressive form of NAFLD. The Pathology Committee of the NASH ... Cited by 473 - Related articles - View as HTML - All 6 versions
- ►nih.gov KL Donnelly, CI Smith, SJ Schwarzenberg, … - Journal of Clinical …, 2005 - Am Soc Clin Investig 1 Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St. Paul,
Minnesota, USA. 2 Department of Medicine, Division of Gastroenterology, Hepatology and
Nutrition, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA. 3 Minnesota ... Cited by 294 - Related articles - All 9 versions
