MA Creager, TF Luscher, F Cosentino, JA Beckman - Circulation, 2003 - Am Heart Assoc Diabetes mellitus affects approximately 100 million persons worldwide. 1 Five to ten percent
have type 1 (formerly known as insulin-dependent) and 90% to 95% have type 2
(non–insulin-dependent) diabetes mellitus. It is likely that the incidence of type 2 diabetes ... Cited by 405 - Related articles - BL Direct - All 6 versions
- ►ucsf.edu [PDF] GA Francis, E Fayard, F Picard, J Auwerx - Annual review of physiology, 2003 - Annual Reviews ▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological sensors, enabling
the organism to quickly adapt to environmental changes by inducing the appropriate metabolic
genes and pathways. Ligands for these metabolic receptors are compounds from dietary ... Cited by 258 - Related articles - BL Direct - All 7 versions
- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & …, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle and
impaired insulin secretion. Considerable evidence also implicates deranged adipocyte metabolism
and altered fat topography in the pathogenesis of glucose intolerance in T2DM. 1) Fat ... Cited by 245 - Related articles - All 4 versions
I Bogacka, H Xie, GA Bray, SR Smith - Diabetes, 2005 - Am Diabetes Assoc Thiazolidenediones such as pioglitazone improve insulin sensitivity in diabetic patients by several
mechanisms, including increased uptake and metabolism of free fatty acids in adipose
tissue. The purpose of the present study was to determine the effect of pioglitazone on ... Cited by 122 - Related articles - All 5 versions
A Misra, NK Vikram - Nutrition, 2003 - Elsevier Abdominal obesity contributes significantly to the metabolic perturbations and cardiovascular
risk in human beings. Abdominal adipose tissue depots (intraabdominal and subcutaneous
[deep subcutaneous, posterior subcutaneous]) are metabolically active and appear to be ... Cited by 113 - Related articles - All 11 versions
- ►endojournals.org KM Utzschneider, SE Kahn - Journal of Clinical Endocrinology & …, 2006 - Endocrine Soc Evidence Synthesis: Insulin resistance in NAFLD is characterized by reductions in
whole-body, hepatic, and adipose tissue insulin sensitivity. The mechanisms underlying the accumulation
of fat in the liver may include excess dietary fat, increased delivery of free fatty acids to the ... Cited by 116 - Related articles - BL Direct - All 4 versions
TM Larsen, S Toubro, A Astrup - International journal of obesity, 2003 - nature.com The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR ) is
a member of the PPAR family. The endogenous activators of all members of the PPAR family
are a variety of fatty acids, which suggests that the PPARs are highly involved in lipid ... Cited by 108 - Related articles - BL Direct - All 5 versions
I Bogacka, H Xie, GA Bray, SR Smith - Diabetes Care, 2004 - Am Diabetes Assoc RESULTS—Pioglitazone treatment increased the expression of genes involved in
glycerol-3-phosphate synthesis. The mRNA expression of PEPCK-C and glycerol-3-phosphate
dehydrogenase (GPDH) increased (P < 0.01) in patients treated with pioglitazone. There ... Cited by 103 - Related articles - BL Direct - All 8 versions
- ►endojournals.org AM Sharma, B Staels - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Conclusions: PPAR is highly expressed in adipose tissue, where its activation with thiazolidinediones
alters fat topography and adipocyte phenotype and up-regulates genes involved in fatty acid
metabolism and triglyceride storage. Furthermore, PPAR activation is associated with ... Cited by 99 - Related articles - BL Direct - All 3 versions
L Heilbronn, SR Smith, E Ravussin - International Journal of Obesity, 2004 - nature.com CONCLUSIONS: The novel paradigms of ectopic fat and fat cell as an endocrine organ probably
will constitute a new framework for the study of the links between our obesigenic environment
and the risk of developing diabetes. (a) Ectopic fat storage syndrome. Three lines of ... Cited by 90 - Related articles - All 4 versions
