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Scholar Results 1 - 10 of about 67 citing Edgerton: Small increases in insulin inhibit hepatic glucose production solely caused by.... (0.09 sec) 

FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis

- physiology.org
G Boden, P Cheung, TP Stein, K Kresge, M … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc
Free fatty acids (FFA) have been shown to inhibit insulin suppression of
endogenous glucose production (EGP). To determine whether this is the result of
stimulation by FFA of gluconeogenesis (GNG) or glycogenolysis (GL) or a ...
Cited by 121 - Related articles - BL Direct - All 5 versions

Metabolic effects of visceral fat accumulation in type 2 diabetes

- endojournals.org
A Gastaldelli, Y Miyazaki, M Pettiti, M … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc
Visceral fat (VF) excess has been associated with decreased peripheral insulin
sensitivity and has been suggested to contribute to hepatic insulin resistance.
However, the mechanisms by which VF impacts on hepatic glucose metabolism ...
Cited by 71 - Related articles - BL Direct - All 4 versions

Effects of free fatty acids per se on glucose production, gluconeogenesis, and …


P Staehr, O Hother-Nielsen, BR Landau, V … - Diabetes, 2003 - Am Diabetes Assoc
Insulin-independent effects of a physiological increase in free fatty acid (FFA)
levels on fasting glucose production, gluconeogenesis, and glycogenolysis were
assessed by administering [6,6- 2 H 2 ]-glucose and deuteriated water ( 2 H ...
Cited by 40 - Related articles - BL Direct - All 5 versions

Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats

- physiology.org
IE Peterside, MA Selak, RA Simmons - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc
Intrauterine growth retardation (IUGR) has been linked to the development of
type 2 diabetes in adulthood. We have developed an IUGR model in the rat whereby
the animals develop diabetes between 3 and 6 mo of age that is associated ...
Cited by 37 - Related articles - BL Direct - All 3 versions

Separate contribution of diabetes, total fat mass, and fat topography to glucose production …

- endojournals.org
A Gastaldelli, Y Miyazaki, M Pettiti, E … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc
The contribution of increased gluconeogenesis (GNG) to the excessive rate of
endogenous glucose production (EGP) in type 2 diabetes (T2DM) is well
established. However, the separate effects of obesity (total body fat), ...
Cited by 35 - Related articles - BL Direct - All 5 versions

Free fatty acids, insulin resistance, and pregnancy


E Sivan, G Boden - Current Diabetes Reports, 2003 - Springer
Introduction Free fatty acids (FFAs) are important oxidative fuels for many body
tissues, including the heart, skeletal muscle, and liver. Their physiologic role
becomes particularly prominent during periods of starvation, prolonged ...
Cited by 34 - Related articles - BL Direct - All 2 versions

Higher insulin concentrations are required to suppress gluconeogenesis than …


A Adkins, R Basu, M Persson, B Dicke, P … - Diabetes, 2003 - Am Diabetes Assoc
To determine the mechanism(s) by which insulin inhibits endogenous glucose
production (EGP) in nondiabetic humans, insulin was infused at rates of 0.25,
0.375, or 0.5 mU · kg −1 · min −1 and glucose was clamped at ∼5.5 ...
Cited by 30 - Related articles - BL Direct - All 4 versions

Physiologic action of insulin


PJ Flakoll, MD Jensen, AD Cherrington - Diabetes mellitus: a fundamental and clinical text - books.google.com
PHYSIOLOGIC ACTION OF INSULIN PAUL J. FLAKOLL MICHAEL D. JENSEN ALAN D.
CHERRINCTON Insulin is commonly felt to be the primary regulator of the blood
glucose level. Indeed, an absence of insulin results in an elevated blood ...
Cited by 29 - Related articles

Both fasting glucose production and disappearance are abnormal in people with" mild" and" …

- physiology.org
R Basu, WF Schwenk, RA Rizza - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc
To determine whether regulation of fasting endogenous glucose production (EGP)
and glucose disappearance (R d ) are both abnormal in people with type 2
diabetes, EGP and R d were measured in 7 "severe" (SD), 9 "mild" (MD), and ...
Cited by 28 - Related articles - All 3 versions

Effects of free fatty acids on gluconeogenesis and glycogenolysis


G Boden - Life sciences, 2003 - Elsevier
Gluconeogenesis (GNG), ie, the formation of glucose from non-glucose precursors,
provides the glucose needed by the central nervous system during prolonged
fasting and therefore is essential for survival during starvation [12]. ...
Cited by 25 - Related articles - All 5 versions


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